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Peptide record

TPDB12860

Antibacterial Antifungal Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB12860
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
INWKKIAKKVAGML
Physicochemical Analysis
C75H130N20O16S1
RDCEQHFPSTY
K
1600.04
11.00
4
0
8
+4
0.86
0.150
118.57
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
343.74
1
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
1
L
4
K
1
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 1 K: 4 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
14
C75H130N20O16S1
1600.04
11.00
+4
0.86
0.150
Evidence Records 6 records
Evidence 1 Activity

Activity

<10% Degranulation
Toxicity
160 µM
Cytotoxic
<10% Degranulation | 160 | µM | target cell: Rat peritoneal mast cells

Target

Rat peritoneal mast cells

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015
Evidence 2 Activity

Activity

15% Degranulation
Toxicity
300 µM
Cytotoxic
15% Degranulation | 300 | µM | target cell: Rat peritoneal mast cells

Target

Rat peritoneal mast cells

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015
Evidence 3 Activity

Activity

30% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
30% Hemolysis | 100 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015
Evidence 4 Activity

Activity

40% Hemolysis
Toxicity
160-300 µM
Hemolytic Cytotoxic
40% Hemolysis | 160-300 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015
Evidence 5 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Study of mastoparan analog peptides against Candida albicans and safety in zebrafish embryos (Danio rerio). | Future Microbiol | 2019
Evidence 6 Activity

Activity

LC50
Toxicity
9.64 µg/mL
Cytotoxic
LC50 | 9.64 | µg/mL | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
Study of mastoparan analog peptides against Candida albicans and safety in zebrafish embryos (Danio rerio). | Future Microbiol | 2019