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Peptide record

TPDB12857

Antibacterial Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB12857
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, DRAMP, and Peptipedia, with an available 3D structural model.
Sequence
GNLKALLAVAKKIL
Physicochemical Analysis
C68H126N18O16
RDCEQHMFPSTWY
L
1451.86
10.84
3
0
9
+3
0.41
0.979
181.43
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
3
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
4
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 4 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
14
C68H126N18O16
1451.86
10.84
+3
0.41
0.979
Evidence Records 4 records
Evidence 1 Activity

Activity

8% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
8% Hemolysis | 256 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria. | Eur J Pharm Sci | 2020
Evidence 2 Activity

Activity

80% Killing
Toxicity
128 µM
Cytotoxic
80% Killing | 128 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria. | Eur J Pharm Sci | 2020
Evidence 3 Activity

Activity

IC50
Toxicity
128 µM
Cytotoxic
IC50 | 128 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria. | Eur J Pharm Sci | 2020
Evidence 4 Activity

Activity

IC50
Toxicity
128 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.33285267]8% hemolysis against mouse erythrocytes at 256 µM. | Cytotoxicity: [Ref.33285267]80% Killing against Human embryonic kidney HEK293T cells at 128 µM Human embryonic kidney HEK293T cells(IC50=128 µM).

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Pharm Sci. 2021 Mar 1 158:105665.