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Peptide record

TPDB12853

Antibacterial Antifungal Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB12853
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 14-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
KFLPKIFCAITKKC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C78H130N18O16S2
RNDEQGHMSWYV
K
1640.12
10.17
4
0
6
+4
-0.02
0.521
90.71
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
125
0.08
3
Residue Composition
number
1
A
0
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
2
I
1
L
4
K
0
M
2
F
1
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 4 M: 0 F: 2 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
14 reviewed residue count
C78H130N18O16S2 sequence-only estimate (linear, free termini)
1640.12 sequence-only estimate (linear, free termini)
10.17 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
-0.02 sequence-only estimate (linear, free termini)
0.521 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
154 µM
Hemolytic Cytotoxic
10% Hemolysis | 154 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Modification and Targeted Design of N-Terminal Truncates Derived from Brevinin with Improved Therapeutic Efficacy | Biology (Basel) | 2020