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Peptide record

TPDB12833

Antibacterial Anticancer Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB12833
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
GLLKKLLKKLLKKL
Physicochemical Analysis
C80H154N20O15
ARNDCEQHIMFPSTWYV
L
1636.23
11.21
6
0
7
+6
2.03
0.200
195.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
7
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 7 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C80H154N20O15
1636.23
11.21
+6
2.03
0.200
Evidence Records 5 records
Evidence 1 Activity

Activity

HC50
Hemolysis
30 µM
Human erythrocytes: HC50=30 µM

Target

Human erythrocytes

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Cell death
Toxicity
11 µM
Cytotoxic
50% Cell death | 11 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Amino acid side chains affect the bioactivity of designed short peptide amphiphiles | J Mater Chem B | 2016
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
30 µM
Hemolytic Cytotoxic
50% Hemolysis | 30 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Amino acid side chains affect the bioactivity of designed short peptide amphiphiles | J Mater Chem B | 2016
Evidence 4 Activity

Activity

HC50
Toxicity
30 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50=30 µM | Cytotoxicity: Human keratinocytes HaCat: >90% Killing=40 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Evidence 5 Hemolysis

Activity

30 µM
HC50
Human erythrocytes: HC50=30 µM
Hemolysis

Target

Human erythrocytes

Source & Reference

PD_Hemolysis
DRAMP4
PD_Hemolysis