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Peptide record

TPDB12825

Antibacterial Anticancer Antifungal Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB12825
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
GLFDIVKKVLKLLK
Physicochemical Analysis
C79H140N18O17
ARNCEQHMPSTWY
LK
1614.09
10.55
4
1
8
+3
1.66
0.814
180.71
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
1
D
0
C
0
E
0
Q
1
G
0
H
1
I
4
L
4
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 4 K: 4 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
14
C79H140N18O17
1614.09
10.55
+3
1.66
0.814
Evidence Records 3 records
Evidence 1 Activity

Activity

<=5% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
<=5% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Morphing of Amphipathic Helices to Explore the Activity and Selectivity of Membranolytic Antimicrobial Peptides. | Biochemistry | 2020
Evidence 2 Activity

Activity

50% Cell death
Toxicity
85 µM
Cytotoxic
50% Cell death | 85 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
Morphing of Amphipathic Helices to Explore the Activity and Selectivity of Membranolytic Antimicrobial Peptides. | Biochemistry | 2020
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Angew Chem Int Ed Engl. 2019 Feb 4 58(6):1674-1678.