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Peptide record

TPDB12820

Antibacterial Anticancer Antifungal Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB12820
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia dbACP AFP-GFuse
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
LNLKKLLKVAKKIL
Physicochemical Analysis
C78H148N20O16
RDCEQGHMFPSTWY
LK
1622.16
11.12
5
0
8
+5
2.16
0.464
195.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
5
L
5
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 5 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
14
C78H148N20O16
1622.16
11.12
+5
2.16
0.464
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
32 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram+ S. aureus ATCC 25923 (MIC 32 uM), B. cereus ATCC 11778 (MIC 16 uM), E. faecalis ATCC 29212 (MIC 4 uM), L. monocytogenes AT
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µM

Target

B. cereus ATCC 11778

Source & Reference

DRAMP

Other

active against Gram+ S. aureus ATCC 25923 (MIC 32 uM), B. cereus ATCC 11778 (MIC 16 uM), E. faecalis ATCC 29212 (MIC 4 uM), L. monocytogenes ATCC 15313 (MIC 4 uM), Gram- E. coli
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

DRAMP

Other

active against Gram+ S. aureus ATCC 25923 (MIC 32 uM), B. cereus ATCC 11778 (MIC 16 uM), E. faecalis ATCC 29212 (MIC 4 uM), L. monocytogenes ATCC 15313 (MIC 4 uM), Gram- E. coli ATCC 25922 (MIC 8 uM), P. aerugino
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µM

Target

L. monocytogenes ATCC 15313

Source & Reference

DRAMP

Other

C 25923 (MIC 32 uM), B. cereus ATCC 11778 (MIC 16 uM), E. faecalis ATCC 29212 (MIC 4 uM), L. monocytogenes ATCC 15313 (MIC 4 uM), Gram- E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 64 uM), S. enterica A
Evidence 5 Activity

Activity

MIC
Antibacterial
8 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

16 uM), E. faecalis ATCC 29212 (MIC 4 uM), L. monocytogenes ATCC 15313 (MIC 4 uM), Gram- E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 64 uM), S. enterica ATCC 13076 (MIC 32 uM), and fungi C. a
Evidence 6 Activity

Activity

MIC
Antibacterial
64 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

(MIC 4 uM), L. monocytogenes ATCC 15313 (MIC 4 uM), Gram- E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 64 uM), S. enterica ATCC 13076 (MIC 32 uM), and fungi C. albicans ATCC 10231 (MIC 16 uM). It als
Evidence 7 Activity

Activity

MIC
Antibacterial
32 µM

Target

S. enterica ATCC 13076

Source & Reference

DRAMP

Other

13 (MIC 4 uM), Gram- E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 64 uM), S. enterica ATCC 13076 (MIC 32 uM), and fungi C. albicans ATCC 10231 (MIC 16 uM). It also showed an effect on cancer cells A
Evidence 8 Activity

Activity

MIC
Antibacterial
16 µM

Target

Candida albicans ATCC 10231

Source & Reference

DRAMP

Other

uM), P. aeruginosa ATCC 27853 (MIC 64 uM), S. enterica ATCC 13076 (MIC 32 uM), and fungi C. albicans ATCC 10231 (MIC 16 uM). It also showed an effect on cancer cells A427 (IC50 5.1 uM), H1975 (IC50 6.25012.5 uM),
Evidence 9 Activity

Activity

MIC
Antifungal
32 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms.
active against Gram+ S. aureus ATCC 25923 (MIC 32 uM), B. cereus ATCC 11778 (MIC 16 uM), E. faecalis ATCC 29212 (MIC 4 uM), L. monocytogenes AT
Evidence 10 Activity

Activity

MIC
Antifungal
16 µM

Target

B. cereus ATCC 11778

Source & Reference

DRAMP

Other

active against Gram+ S. aureus ATCC 25923 (MIC 32 uM), B. cereus ATCC 11778 (MIC 16 uM), E. faecalis ATCC 29212 (MIC 4 uM), L. monocytogenes ATCC 15313 (MIC 4 uM), Gram- E. coli
Evidence 11 Activity

Activity

MIC
Antifungal
4 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

DRAMP

Other

active against Gram+ S. aureus ATCC 25923 (MIC 32 uM), B. cereus ATCC 11778 (MIC 16 uM), E. faecalis ATCC 29212 (MIC 4 uM), L. monocytogenes ATCC 15313 (MIC 4 uM), Gram- E. coli ATCC 25922 (MIC 8 uM), P. aerugino
Evidence 12 Activity

Activity

MIC
Antifungal
4 µM

Target

L. monocytogenes ATCC 15313

Source & Reference

DRAMP

Other

C 25923 (MIC 32 uM), B. cereus ATCC 11778 (MIC 16 uM), E. faecalis ATCC 29212 (MIC 4 uM), L. monocytogenes ATCC 15313 (MIC 4 uM), Gram- E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 64 uM), S. enterica A
Evidence 13 Activity

Activity

MIC
Antifungal
8 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

16 uM), E. faecalis ATCC 29212 (MIC 4 uM), L. monocytogenes ATCC 15313 (MIC 4 uM), Gram- E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 64 uM), S. enterica ATCC 13076 (MIC 32 uM), and fungi C. a
Evidence 14 Activity

Activity

MIC
Antifungal
64 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

(MIC 4 uM), L. monocytogenes ATCC 15313 (MIC 4 uM), Gram- E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 64 uM), S. enterica ATCC 13076 (MIC 32 uM), and fungi C. albicans ATCC 10231 (MIC 16 uM). It als
Evidence 15 Activity

Activity

MIC
Antifungal
32 µM

Target

S. enterica ATCC 13076

Source & Reference

DRAMP

Other

13 (MIC 4 uM), Gram- E. coli ATCC 25922 (MIC 8 uM), P. aeruginosa ATCC 27853 (MIC 64 uM), S. enterica ATCC 13076 (MIC 32 uM), and fungi C. albicans ATCC 10231 (MIC 16 uM). It also showed an effect on cancer cells A
Evidence 16 Activity

Activity

MIC
Antifungal
16 µM

Target

Candida albicans ATCC 10231

Source & Reference

DRAMP

Other

uM), P. aeruginosa ATCC 27853 (MIC 64 uM), S. enterica ATCC 13076 (MIC 32 uM), and fungi C. albicans ATCC 10231 (MIC 16 uM). It also showed an effect on cancer cells A427 (IC50 5.1 uM), H1975 (IC50 6.25012.5 uM),
Evidence 17 Activity

Activity

15% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
15% Hemolysis | 256 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria. | Eur J Pharm Sci | 2020
Evidence 18 Activity

Activity

% Hemolysis
Toxicity
15 %
Hemolytic
Hemolytic_activity: [Ref.33285267]15% hemolysis against mouse erythrocytes at 256 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Pharm Sci. 2021 Mar 1 158:105665.