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Peptide record

TPDB12805

Antibacterial Antifungal Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB12805
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LRRLLRWLRRLLRR
Physicochemical Analysis
C89H162N36O15
ANDCEQGHIKMFPSTYV
R
1976.50
13.18
7
0
7
+7
0.46
-0.686
167.14
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
278.27
0
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
6
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 6 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
14
C89H162N36O15
1976.50
13.18
+7
0.46
-0.686
Evidence Records 3 records
Evidence 1 Activity

Activity

75% Hemolysis
Toxicity
75 µM
Hemolytic Cytotoxic
75% Hemolysis | 75 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and characterization of short antimicrobial peptides using leucine zipper templates with selectivity towards microorganisms. | Amino Acids | 2014
Evidence 2 Activity

Activity

100% Killing
Toxicity
9 µM
Cytotoxic
100% Killing | 9 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Design and characterization of short antimicrobial peptides using leucine zipper templates with selectivity towards microorganisms. | Amino Acids | 2014
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
15 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.25069749] 15% hemolysis at 10 µg/ml , 25% hemolysis at 20 µg/ml , 30% hemolysis at 30 µg/ml , 40% hemolysis at 40 µg/ml , 50% hemolysis at 50 µg/ml , 55% hemolysis at 60 µg/ml , 70% hemolysis at 70 µg/ml , 80% hemolysis at 80µg/ml against human red blood cells | Cytotoxicity: [Ref.25069749] The cell viability of murine fibroblast cells (3T3) is 85.9%, 77.5%, 73.7%, 50.0%, 23.7% and 0% at peptide concentrations of 1.5, 3, 4.5, 6 and 9 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2014 Nov 46(11):2531-43. doi: 10.1007/s00726-014-1802-3.