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Peptide record

TPDB12803

Antibacterial Antifungal Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB12803
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.
Sequence
RWRLVCFLCRRKKV
Physicochemical Analysis
C84H143N29O15S2
ANDEQGHIMPSTY
R
1863.36
11.96
6
0
6
+6
0.78
-0.207
97.14
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5625
301.87
2
Residue Composition
number
0
A
4
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
0
I
2
L
2
K
0
M
1
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 2 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
14
C84H143N29O15S2
1863.36
11.96
+6
0.78
-0.207
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8.6 µM

Target

B. subtilis 168 HT

Source & Reference

NA

Other

Active against B. subtilis 168 HT (MIC 8.6 uM). E. coli MG1655 (MIC 17.2 uM), and C. trachomatis D/UW-3/Cx (MIC90 6.3 uM). Note that whe
Evidence 2 Activity

Activity

MIC
Antibacterial
17.2 µM

Target

Escherichia coli MG1655

Source & Reference

NA

Other

Active against B. subtilis 168 HT (MIC 8.6 uM). E. coli MG1655 (MIC 17.2 uM), and C. trachomatis D/UW-3/Cx (MIC90 6.3 uM). Note that whether this is a or part of the
Evidence 3 Activity

Activity

MIC
Antifungal
8.6 µM

Target

B. subtilis 168 HT

Source & Reference

Antifungipept

Other

Active against B. subtilis 168 HT (MIC 8.6 uM). E. coli MG1655 (MIC 17.2 uM), and C. trachomatis D/UW-3/Cx (MIC90 6.3 uM). Note that whe
Evidence 4 Activity

Activity

MIC
Antifungal
17.2 µM

Target

Escherichia coli MG1655

Source & Reference

Antifungipept

Other

Active against B. subtilis 168 HT (MIC 8.6 uM). E. coli MG1655 (MIC 17.2 uM), and C. trachomatis D/UW-3/Cx (MIC90 6.3 uM). Note that whether this is a or part of the
Evidence 5 Activity

Activity

30% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
30% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Medicinal leech antimicrobial peptides lacking toxicity represent a promising alternative strategy to combat antibiotic-resistant pathogens. | Eur J Med Chem | 2019