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Peptide record

TPDB12798

Antibacterial Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB12798
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
INWLKIAAAVAGML
Physicochemical Analysis
C69H115N17O16S1
RDCEQHFPSTY
A
1470.84
10.10
1
0
11
+1
-3.01
1.514
160.71
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
373.94
1
Residue Composition
number
4
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
2
L
1
K
1
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 2 K: 1 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
14
C69H115N17O16S1
1470.84
10.10
+1
-3.01
1.514
Evidence Records 4 records
Evidence 1 Activity

Activity

19% Degranulation
Toxicity
160 µM
Cytotoxic
19% Degranulation | 160 | µM | target cell: Rat peritoneal mast cells

Target

Rat peritoneal mast cells

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015
Evidence 2 Activity

Activity

25% Degranulation
Toxicity
300 µM
Cytotoxic
25% Degranulation | 300 | µM | target cell: Rat peritoneal mast cells

Target

Rat peritoneal mast cells

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015
Evidence 3 Activity

Activity

40% Hemolysis
Toxicity
80 µM
Hemolytic Cytotoxic
40% Hemolysis | 80 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015
Evidence 4 Activity

Activity

65% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
65% Hemolysis | 150 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015