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Peptide record

TPDB12795

Antibacterial Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB12795
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
INWLAIAAAVAGML
Physicochemical Analysis
C66H108N16O16S1
RDCEQHKFPSTY
A
1413.74
6.02
0
0
12
-0
-4.17
1.921
167.86
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
389.04
1
Residue Composition
number
5
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
2
I
2
L
0
K
1
M
0
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 5 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 2 L: 2 K: 0 M: 1 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
14
C66H108N16O16S1
1413.74
6.02
-0
-4.17
1.921
Evidence Records 4 records
Evidence 1 Activity

Activity

5% Degranulation
Toxicity
160 µM
Cytotoxic
5% Degranulation | 160 | µM | target cell: Rat peritoneal mast cells

Target

Rat peritoneal mast cells

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015
Evidence 2 Activity

Activity

10% Degranulation
Toxicity
300 µM
Cytotoxic
10% Degranulation | 300 | µM | target cell: Rat peritoneal mast cells

Target

Rat peritoneal mast cells

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015
Evidence 3 Activity

Activity

18% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
18% Hemolysis | 150 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015
Evidence 4 Activity

Activity

42% Hemolysis
Toxicity
300 µM
Hemolytic Cytotoxic
42% Hemolysis | 300 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Structure-activity relationship of mastoparan analogs: Effects of the number and positioning of Lys residues on secondary structure, interaction with membrane-mimetic systems and biological activity. | Peptides | 2015