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Peptide record

TPDB12790

Antibacterial Anticancer Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB12790
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis ToxinPred 3.0
standard
No
A 14-aa standard-residue multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, PD_Hemolysis, and other sources, with an available 3D structural model.
Sequence
LARFVLRILKYGFK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C85H138N22O16
NDCEQHMPSTW
L
1724.17
11.51
4
0
9
+4
0.62
0.643
139.29
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
0.86
1
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
3
L
2
K
0
M
2
F
0
P
0
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 3 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
14 reviewed residue count
C85H138N22O16 sequence-only estimate (linear, free termini)
1724.17 sequence-only estimate (linear, free termini)
11.51 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
0.62 sequence-only estimate (linear, free termini)
0.643 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
9.38 µM
Hemolytic Cytotoxic
10% Hemolysis | 9.38 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of antimicrobial and cytolytic peptides by computational analysis of bacterial, algal, and invertebrate proteomes. | Amino Acids | 2020
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 10% Hemolysis=9.38 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2020 Oct 52(10):1403-1412
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis