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Peptide record

TPDB12787

Antibacterial Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB12787
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, DRAMP, and Peptipedia, with an available 3D structural model.
Sequence
LNLKKLLAVAKKIL
Physicochemical Analysis
C75H141N19O16
RDCEQGHMFPSTWY
L
1565.06
11.00
4
0
9
+4
1.00
0.871
202.14
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
5
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 5 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
14
C75H141N19O16
1565.06
11.00
+4
1.00
0.871
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
64 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram+ S. aureus ATCC 25923 (MIC 64 uM), B. cereus ATCC 11778 (MIC 16 uM), E. faecalis ATCC 29212 (MIC 8 uM), L. monocytogenes AT
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µM

Target

B. cereus ATCC 11778

Source & Reference

DRAMP

Other

active against Gram+ S. aureus ATCC 25923 (MIC 64 uM), B. cereus ATCC 11778 (MIC 16 uM), E. faecalis ATCC 29212 (MIC 8 uM), L. monocytogenes ATCC 15313 (MIC 8 uM), Gram- E. coli
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

DRAMP

Other

active against Gram+ S. aureus ATCC 25923 (MIC 64 uM), B. cereus ATCC 11778 (MIC 16 uM), E. faecalis ATCC 29212 (MIC 8 uM), L. monocytogenes ATCC 15313 (MIC 8 uM), Gram- E. coli ATCC 25922 (MIC 8 uM), P.aeruginos
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

L. monocytogenes ATCC 15313

Source & Reference

DRAMP

Other

C 25923 (MIC 64 uM), B. cereus ATCC 11778 (MIC 16 uM), E. faecalis ATCC 29212 (MIC 8 uM), L. monocytogenes ATCC 15313 (MIC 8 uM), Gram- E. coli ATCC 25922 (MIC 8 uM), P.aeruginosa ATCC 27853 (MIC 128 uM), S. enterica A
Evidence 5 Activity

Activity

MIC
Antibacterial
8 µM

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

16 uM), E. faecalis ATCC 29212 (MIC 8 uM), L. monocytogenes ATCC 15313 (MIC 8 uM), Gram- E. coli ATCC 25922 (MIC 8 uM), P.aeruginosa ATCC 27853 (MIC 128 uM), S. enterica ATCC 13076 (MIC 64 uM), and fungi C. a
Evidence 6 Activity

Activity

MIC
Antibacterial
128 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

(MIC 8 uM), L. monocytogenes ATCC 15313 (MIC 8 uM), Gram- E. coli ATCC 25922 (MIC 8 uM), P.aeruginosa ATCC 27853 (MIC 128 uM), S. enterica ATCC 13076 (MIC 64 uM), and fungi C. albicans ATCC 10231 (MIC 32 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
64 µM

Target

S. enterica ATCC 13076

Source & Reference

DRAMP

Other

13 (MIC 8 uM), Gram- E. coli ATCC 25922 (MIC 8 uM), P.aeruginosa ATCC 27853 (MIC 128 uM), S. enterica ATCC 13076 (MIC 64 uM), and fungi C. albicans ATCC 10231 (MIC 32 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
32 µM

Target

Candida albicans ATCC 10231

Source & Reference

DRAMP

Other

uM), P.aeruginosa ATCC 27853 (MIC 128 uM), S. enterica ATCC 13076 (MIC 64 uM), and fungi C. albicans ATCC 10231 (MIC 32 uM).
Evidence 9 Activity

Activity

10% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
10% Hemolysis | 128 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria. | Eur J Pharm Sci | 2020
Evidence 10 Activity

Activity

30% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
30% Hemolysis | 256 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Newly designed antimicrobial peptides with potent bioactivity and enhanced cell selectivity prevent and reverse rifampin resistance in Gram-negative bacteria. | Eur J Pharm Sci | 2020
Evidence 11 Activity

Activity

% Hemolysis
Toxicity
10 %
Hemolytic
Hemolytic_activity: [Ref.33285267]10% hemolysis against mouse erythrocytes at 128 µM,30% hemolysis against mouse erythrocytes at 256 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Pharm Sci. 2021 Mar 1 158:105665.