Back to search

Peptide record

TPDB12765

Antibacterial Antifungal Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12765
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LRRAARWARRLLRR
Physicochemical Analysis
C80H144N36O15
NDCEQGHIKMFPSTYV
R
1850.26
13.18
7
0
7
+7
1.63
-1.114
105.00
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
297.26
0
Residue Composition
number
3
A
7
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
3
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
14
C80H144N36O15
1850.26
13.18
+7
1.63
-1.114
Evidence Records 3 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
75 µM
Hemolytic Cytotoxic
0% Hemolysis | 75 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and characterization of short antimicrobial peptides using leucine zipper templates with selectivity towards microorganisms. | Amino Acids | 2014
Evidence 2 Activity

Activity

19% Killing
Toxicity
9 µM
Cytotoxic
19% Killing | 9 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Design and characterization of short antimicrobial peptides using leucine zipper templates with selectivity towards microorganisms. | Amino Acids | 2014
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
3 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.25069749] 3% hemolysis at 10 µg/ml , 5% hemolysis at 20 µg/ml , 7.5% hemolysis at 30 µg/ml , 10% hemolysis at 40 µg/ml , 12% hemolysis at 50 µg/ml , 13% hemolysis at 60 µg/ml , 15% hemolysis at 70 µg/ml , 19% hemolysis at 80 µg/ml against human red blood cells | Cytotoxicity: [Ref.25069749] The cell viability of murine fibroblast cells (3T3) is 100%, 93.6%, 86.8%, 82.9%, 80% and 77.9% at peptide concentrations of 1.5, 3, 4.5, 6 and 9 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2014 Nov 46(11):2531-43. doi: 10.1007/s00726-014-1802-3.