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Peptide record

TPDB12760

Antibacterial Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB12760
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GLFNIIKKTIGKLR
Physicochemical Analysis
C75H133N21O17
ADCEQHMPSWYV
IK
1601.01
11.73
4
0
6
+4
1.18
0.193
139.29
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
1
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
2
L
3
K
0
M
1
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 2 K: 3 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C75H133N21O17
1601.01
11.73
+4
1.18
0.193
Evidence Records 1 records
Evidence 1 Activity

Activity

IC50
Toxicity
450.25 µg/mL
Cytotoxic
IC50 | 450.25 | µg/mL | target cell: Human normal skin cells Hu02

Target

Human normal skin cells Hu02

Source & Reference

NA
DBAASP
Alignment-based design and synthesis of new antimicrobial Aurein-derived peptides with improved activity against Gram-negative bacteria and evaluation of their toxicity on human cells. | Drug Dev Res | 2019