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Peptide record

TPDB12759

Antibacterial Anticancer Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB12759
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
INLKKLAARIKKKI
Physicochemical Analysis
C76H145N23O16
DCEQGHMFPSTWYV
K
1637.13
11.85
6
0
7
+6
3.79
-0.200
153.57
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
1
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
3
I
2
L
5
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 3 L: 2 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C76H145N23O16
1637.13
11.85
+6
3.79
-0.200
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4-8 µM

Target

Staphylococcus aureus ATCC 25923 or ATCC 12600 or MRSA

Source & Reference

NA

Other

+ 001812446 or BL21 (MIC 2-8 uM), K-pneumoniae ATCC 13883 or KpC+ 001825971 (MIC >32 uM), S. aureus ATCC 25923 or ATCC 12600 or MRSA (MIC 4-8 uM), P. aeruginosa PA14 or PAO1 (MIC 4 uM).
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

Pseudomonas aeruginosa PA14 or PAO1

Source & Reference

NA

Other

or KpC+ 001825971 (MIC >32 uM), S. aureus ATCC 25923 or ATCC 12600 or MRSA (MIC 4-8 uM), P. aeruginosa PA14 or PAO1 (MIC 4 uM).
Evidence 3 Activity

Activity

50% Cell death
Toxicity
>100 µM
Cytotoxic
50% Cell death | >100 | µM | target cell: Mouse fibroblasts 3T3-L1

Target

Mouse fibroblasts 3T3-L1

Source & Reference

NA
DBAASP
Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants With Extended Antibacterial Properties | J Med Chem | 2019
Evidence 4 Activity

Activity

50% Cell death
Toxicity
>100 µM
Cytotoxic
50% Cell death | >100 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants With Extended Antibacterial Properties | J Med Chem | 2019
Evidence 5 Activity

Activity

8% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
8% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Computer-Aided Design of Mastoparan-like Peptides Enables the Generation of Nontoxic Variants With Extended Antibacterial Properties | J Med Chem | 2019
Evidence 6 Activity

Activity

% Hemolysis
Toxicity
8 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 8% Hemolysis=100 µM | Cytotoxicity: 3T3-L1: 50% Cell death>100 µM HUVEC: 50% Cell death>100 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2019 Sep 12 62(17):8140-8151.