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Peptide record

TPDB12753

Antibacterial Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB12753
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
WIKIWKKIIKKWKK
Physicochemical Analysis
C99H160N24O15
ARNDCEQGHLMFPSTYV
K
1926.51
11.29
7
0
7
+7
0.14
-0.857
111.43
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
16500
856.47
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
4
I
0
L
7
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 4 L: 0 K: 7 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
14
C99H160N24O15
1926.51
11.29
+7
0.14
-0.857
Evidence Records 3 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
5% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Multiple Strategy Optimization of Specifically Targeted Antimicrobial Peptide Based on Structure - Activity Relationships to Enhance Bactericidal Efficiency. | ACS Biomater Sci Eng | 2020
Evidence 2 Activity

Activity

96% Killing
Toxicity
128 µM
Cytotoxic
96% Killing | 128 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Multiple Strategy Optimization of Specifically Targeted Antimicrobial Peptide Based on Structure - Activity Relationships to Enhance Bactericidal Efficiency. | ACS Biomater Sci Eng | 2020
Evidence 3 Activity

Activity

63% Killing
Toxicity
128 µM
Cytotoxic
63% Killing | 128 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
Multiple Strategy Optimization of Specifically Targeted Antimicrobial Peptide Based on Structure - Activity Relationships to Enhance Bactericidal Efficiency. | ACS Biomater Sci Eng | 2020