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Peptide record

TPDB12752

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12752
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse CAFPdb dbAMP 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KLGALWNVAKSKF
Physicochemical Analysis
C70H112N18O16
RDCEQHIMPTY
K
1461.77
10.84
3
0
7
+3
-0.84
0.069
97.69
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
376.26
2
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
2
L
3
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 3 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
13
C70H112N18O16
1461.77
10.84
+3
-0.84
0.069
Evidence Records 2 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
<5% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1. | Eur J Pharm Sci | 2019
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31181304] 0% hemolysis at 100 µmol/L against human red blood cells | Cytotoxicity: [Ref.31181304] The cell viability of MCF-7 cells induced by [Lys1][Lys12]-VmCT1-NH2 is 105%, 110%, 95%, 100%, 110%, 120%, 120% and 120% at peptide concentrations of 0.8, 1.6, 3.1, 12.5, 25, 50 and 100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Pharm Sci. 2019 Jun 7 136:104952. doi: 10.1016/j.ejps.2019.06.006.