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Peptide record

TPDB12749

Antibacterial Anticancer Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12749
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
VRRFKWWWKFLRR
Physicochemical Analysis
C98H142N30O14
ANDCEQGHIMPSTY
R
1964.40
12.88
6
0
7
+6
-3.08
-1.146
52.31
Mammalian: 100 hour Yeast: >20 hour E.coli: >10 hour
16500
839.95
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
1
L
2
K
0
M
2
F
0
P
0
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 1 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
13
C98H142N30O14
1964.40
12.88
+6
-3.08
-1.146
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
Toxicity
32 µM
Cytotoxic
IC50 | 32 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Effects of Pro --> peptoid residue substitution on cell selectivity and mechanism of antibacterial action of tritrpticin-amide antimicrobial peptide. | Biochemistry | 2006
Evidence 2 Activity

Activity

5% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
5% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of Pro --> peptoid residue substitution on cell selectivity and mechanism of antibacterial action of tritrpticin-amide antimicrobial peptide. | Biochemistry | 2006
Evidence 3 Activity

Activity

8% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
8% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of Pro --> peptoid residue substitution on cell selectivity and mechanism of antibacterial action of tritrpticin-amide antimicrobial peptide. | Biochemistry | 2006
Evidence 4 Activity

Activity

20% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
20% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochemistry. 2006 Oct 31 45(43):13007-17.