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Peptide record

TPDB12735

Antibacterial Anticancer Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12735
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
LWKAAAKAAAKLL
Physicochemical Analysis
C65H111N17O14
RNDCEQGHIMFPSTYV
A
1354.70
10.84
3
0
10
+3
-1.58
0.738
136.15
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
5500
405.99
0
Residue Composition
number
6
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
3
L
3
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 3 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
13
C65H111N17O14
1354.70
10.84
+3
-1.58
0.738
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1-8 µM

Target

Escherichia coli ATCC25922 or K88 or CVCC 1515 or UB1005

Source & Reference

NA

Other

active against Gram- E. coli ATCC25922 or K88 or CVCC 1515 or UB1005 (MIC 1-8 uM), B. pyocyaneum ATCC 27853 (MIC 4 uM), S. typhimurium ATCC 14028 (MIC 32 uM), Gram+ S. aur
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

B. pyocyaneum ATCC 27853

Source & Reference

NA

Other

active against Gram- E. coli ATCC25922 or K88 or CVCC 1515 or UB1005 (MIC 1-8 uM), B. pyocyaneum ATCC 27853 (MIC 4 uM), S. typhimurium ATCC 14028 (MIC 32 uM), Gram+ S. aureus ATCC 29213 (MIC 4 uM) and S. epid
Evidence 3 Activity

Activity

MIC
Antibacterial
32 µM

Target

S. typhimurium ATCC 14028

Source & Reference

NA

Other

TCC25922 or K88 or CVCC 1515 or UB1005 (MIC 1-8 uM), B. pyocyaneum ATCC 27853 (MIC 4 uM), S. typhimurium ATCC 14028 (MIC 32 uM), Gram+ S. aureus ATCC 29213 (MIC 4 uM) and S. epidermidis ATCC 12228 (MIC 4 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus ATCC 29213

Source & Reference

NA

Other

-8 uM), B. pyocyaneum ATCC 27853 (MIC 4 uM), S. typhimurium ATCC 14028 (MIC 32 uM), Gram+ S. aureus ATCC 29213 (MIC 4 uM) and S. epidermidis ATCC 12228 (MIC 4 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

NA

Other

C 4 uM), S. typhimurium ATCC 14028 (MIC 32 uM), Gram+ S. aureus ATCC 29213 (MIC 4 uM) and S. epidermidis ATCC 12228 (MIC 4 uM).
Evidence 6 Activity

Activity

5% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
5% Hemolysis | 256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of terminal arrangement of tryptophan on biological activity of symmetric ?-helix-forming peptides. | Chem Biol Drug Des | 2019