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Peptide record

TPDB12734

Antibacterial Anticancer Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12734
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 13-aa standard-residue multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
WIKAAAKAAAKIW
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C70H110N18O14
RNDCEQGHLMFPSTYV
A
1427.76
10.84
3
0
10
+3
-0.67
0.485
106.15
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
7.70
0
Residue Composition
number
6
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
13 reviewed residue count
C70H110N18O14 sequence-only estimate (linear, free termini)
1427.76 sequence-only estimate (linear, free termini)
10.84 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
-0.67 sequence-only estimate (linear, free termini)
0.485 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
5% Hemolysis | 256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Symmetrical Modification of Minimized Dermaseptins to Extend the Spectrum of Antimicrobials with Endotoxin Neutralization Potency. | Int J Mol Sci | 2019
Evidence 2 Activity

Activity

4% Killing
Toxicity
64 µM
Cytotoxic
4% Killing | 64 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Symmetrical Modification of Minimized Dermaseptins to Extend the Spectrum of Antimicrobials with Endotoxin Neutralization Potency. | Int J Mol Sci | 2019
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
15 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.30897850] 15% hemolysis at 256µM against human red blood cells | Cytotoxicity: [Ref.30897850] ①The cell viability of RAW 264.7 induced by WI is 104.0%, 98.2%, 98.6%, 106.5%, 103.6%, 101.8% and 100% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 µM, while the cytotoxicity of WV on RAW 264.7 cells (Control samples) is 93.1%, 67.8%, 37.7%, 17.8%, 0%, 1.4% and 1.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 µM.②The cell viability of HEK293T induced by WV is 98.9%, 99.3%, 107.2%, 99.6%, 110.5%, 108.3%, 96.7% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 µM, while the cytotoxicity of WV on HEK293T cells (Control samples) is 101.4%, 80.1%, 31.9%, 1.4%, 1.4%, 1.8% and 1.1% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2019 Mar 20(6): 1417. Published online 2019 Mar 20. doi: 10.3390/ijms20061417