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Peptide record

TPDB12713

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12713
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
AAKLLLKLLLKAA
Physicochemical Analysis
C66H124N16O14
RNDCEQGHIMFPSTWYV
L
1365.81
10.84
3
0
10
+3
-1.07
1.408
210.77
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
0
Residue Composition
number
4
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
6
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 6 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C66H124N16O14
1365.81
10.84
+3
-1.07
1.408
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1-32 µM

Target

Escherichia coli ATCC25922 or K88 or CVCC 1515 or UB1005

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram- E. coli ATCC25922 or K88 or CVCC 1515 or UB1005 (MIC 1-32 uM), B.pyocyaneum ATCC 27853 (MIC > 128 uM), S.typhimurium ATCC 14028 (MIC >128 uM), S.pullor
Evidence 2 Activity

Activity

MIC
Antibacterial
>128 µM

Target

S.typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP

Other

5922 or K88 or CVCC 1515 or UB1005 (MIC 1-32 uM), B.pyocyaneum ATCC 27853 (MIC > 128 uM), S.typhimurium ATCC 14028 (MIC >128 uM), S.pullorum C79–13 (MIC > 128 uM), Gram+ S. aureus ATCC 29213 (MIC 32 uM), S. epidermidis
Evidence 3 Activity

Activity

MIC
Antibacterial
32 µM

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP DRAMP

Other

128 uM), S.typhimurium ATCC 14028 (MIC >128 uM), S.pullorum C79–13 (MIC > 128 uM), Gram+ S. aureus ATCC 29213 (MIC 32 uM), S. epidermidis ATCC 12228 (MIC 16 uM), S. faecalis ATCC 29212 (MIC 16 uM), and B. subtil
Evidence 4 Activity

Activity

MIC
Antibacterial
16 µM

Target

Staphylococcus epidermidis ATCC 12228

Source & Reference

dbAMP DRAMP

Other

(MIC >128 uM), S.pullorum C79–13 (MIC > 128 uM), Gram+ S. aureus ATCC 29213 (MIC 32 uM), S. epidermidis ATCC 12228 (MIC 16 uM), S. faecalis ATCC 29212 (MIC 16 uM), and B. subtilis CMCC 63501 (MIC 16 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
16 µM

Target

S. faecalis ATCC 29212

Source & Reference

dbAMP DRAMP

Other

> 128 uM), Gram+ S. aureus ATCC 29213 (MIC 32 uM), S. epidermidis ATCC 12228 (MIC 16 uM), S. faecalis ATCC 29212 (MIC 16 uM), and B. subtilis CMCC 63501 (MIC 16 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
16 µM

Target

B. subtilis CMCC 63501

Source & Reference

dbAMP DRAMP

Other

IC 32 uM), S. epidermidis ATCC 12228 (MIC 16 uM), S. faecalis ATCC 29212 (MIC 16 uM), and B. subtilis CMCC 63501 (MIC 16 uM).
Evidence 7 Activity

Activity

5% Hemolysis
Toxicity
8 µM
Hemolytic Cytotoxic
5% Hemolysis | 8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational design of mirror-like peptides with alanine regulation. | Amino Acids | 2016
Evidence 8 Activity

Activity

10% Killing
Toxicity
128 µM
Cytotoxic
10% Killing | 128 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Rational design of mirror-like peptides with alanine regulation. | Amino Acids | 2016
Evidence 9 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26385363] MHC5=8 µM against human red blood cells | Cytotoxicity: [Ref.26385363] The cell viability of HEK293 cells induced by KL6A4 is 102.8%, 109.4%, 103.9%, 109.4%, 105.3%, 90.6%, 83.1% and 81.7% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 µM. The cell viability of HEK293 cells induced by control Me

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2016 Feb 48(2):403-17. doi: 10.1007/s00726-015-2094-y.