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Peptide record

TPDB12712

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12712
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb dbAMP 3.0
standard
No
A 13-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KLGALWNVAKSVF
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C69H109N17O16
RDCEQHIMPTY
ALKV
1432.73
10.60
2
0
8
+2
-0.51
0.692
120.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
3.84
2
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
2
L
2
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 2 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
13 reviewed residue count
C69H109N17O16 sequence-only estimate (linear, free termini)
1432.73 sequence-only estimate (linear, free termini)
10.60 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
-0.51 sequence-only estimate (linear, free termini)
0.692 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
<5% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1. | Eur J Pharm Sci | 2019
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
15 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31181304] 15% hemolysis at 25 µmol/L, 25% hemolysis at 50 µmol/L, 40% hemolysis at 100 µmol/L against human red blood cells | Cytotoxicity: [Ref.31181304] The cell viability of MCF-7 cells induced by [Lys1]-VmCT1-NH2 is 120%, 120%, 120%, 110%, 120%, 120%, 115% and 115% at peptide concentrations of 0.8, 1.6, 3.1, 12.5, 25, 50 and 100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Pharm Sci. 2019 Jun 7 136:104952. doi: 10.1016/j.ejps.2019.06.006.