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Peptide record

TPDB12712

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12712
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb dbAMP 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KLGALWNVAKSVF
Physicochemical Analysis
C69H109N17O16
RDCEQHIMPTY
ALKV
1432.73
10.60
2
0
8
+2
-1.76
0.692
120.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
383.88
2
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
2
L
2
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 2 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
13
C69H109N17O16
1432.73
10.60
+2
-1.76
0.692
Evidence Records 2 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
<5% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1. | Eur J Pharm Sci | 2019
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
15 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31181304] 15% hemolysis at 25 µmol/L, 25% hemolysis at 50 µmol/L, 40% hemolysis at 100 µmol/L against human red blood cells | Cytotoxicity: [Ref.31181304] The cell viability of MCF-7 cells induced by [Lys1]-VmCT1-NH2 is 120%, 120%, 120%, 110%, 120%, 120%, 115% and 115% at peptide concentrations of 0.8, 1.6, 3.1, 12.5, 25, 50 and 100 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Pharm Sci. 2019 Jun 7 136:104952. doi: 10.1016/j.ejps.2019.06.006.