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Peptide record

TPDB12709

Antibacterial Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12709
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
GLSLLLKLGLKLL
Physicochemical Analysis
C67H125N15O15
ARNDCEQHIMFPTWYV
L
1380.82
10.60
2
0
8
+2
-2.35
1.615
240.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
8
L
2
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 8 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C67H125N15O15
1380.82
10.60
+2
-2.35
1.615
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.8 µM

Target

Staphylococcus aureus USA300

Source & Reference

NA

Other

Active against S. aureus USA300 (MIC 0.8 uM), P-aeruginosa PAO1 (MIC > 25 uM), E-coli ATCC 25922 (MIC> 25 uM), and K-pneumonia ATCC138
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
<25 µM
Hemolytic Cytotoxic
50% Hemolysis | <25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens. | Proc Natl Acad Sci U S A | 2019
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis