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Peptide record

TPDB12699

Antibacterial Anticancer Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12699
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
FLGALWHALSHLL
Physicochemical Analysis
C73H108N18O15
RNDCEQIKMPTYV
L
1477.77
8.00
2
0
9
+0
-4.06
1.300
165.38
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
372.18
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
2
H
0
I
5
L
0
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 2 I: 0 L: 5 K: 0 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
13
C73H108N18O15
1477.77
8.00
+0
-4.06
1.300
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
Toxicity
>120 µM
Cytotoxic
IC50 | >120 | µM | target cell: Normal breast cells MCF-10a

Target

Normal breast cells MCF-10a

Source & Reference

NA
DBAASP
Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria. | Arch Microbiol | 2012
Evidence 2 Activity

Activity

0% Hemolysis
Toxicity
30 µM
Hemolytic Cytotoxic
0% Hemolysis | 30 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria. | Arch Microbiol | 2012
Evidence 3 Activity

Activity

IC50
Toxicity
120 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 0% Hemolysis=30 µM | Cytotoxicity: MCF-10A: IC50>120 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Arch Microbiol. 2012 Sep 194(9):769-78.