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Peptide record

TPDB12688

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12688
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 13-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GLIRPKYSIIRWL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C78H127N21O16
ANDCEQHMFTV
I
1615.00
11.39
3
0
7
+3
0.85
0.246
150.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6990
4.33
2
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
2
L
1
K
0
M
0
F
1
P
1
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 2 K: 1 M: 0 F: 0 P: 1 S: 1 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
13 reviewed residue count
C78H127N21O16 sequence-only estimate (linear, free termini)
1615.00 sequence-only estimate (linear, free termini)
11.39 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
0.85 sequence-only estimate (linear, free termini)
0.246 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
5% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel design of short antimicrobial peptides derived from the bactericidal domain of avian ?-defensin-4. | Protein Pept Lett | 2012