TPDB

3D PDB MODEL

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TPDB ID TPDB12672

Activity

Antibacterial Anticancer Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.

Sequence

WLKAAAKAAAKLW

FASTA

>TPDB12672|Antibacterial;Anticancer;Toxicity|length=13
WLKAAAKAAAKLW

Formula C70H110N18O14

Absent Amino Acids RNDCEQGHIMFPSTYV

Common Amino Acids A

Mass 1427.76

PI 10.84

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 10

Net Charge +3

Boman Index -2.87

Hydrophobicity 0.377

Aliphatic Index 106.15

Half Life

Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 11000

Absorbance 280nm 770.44

Polar Residues 0

number

6

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

2

L

3

K

0

M

0

F

0

P

0

S

0

T

2

W

0

Y

0

V

Amino Acid Distribution

A: 6 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0

Length

13

Formula

C70H110N18O14

Mass

1427.76

PI

10.84

Net Charge

+3

Boman Index

-2.87

Hydrophobicity

0.377

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.5-4 µM

Target

Target Organism Escherichia coli ATCC25922 or K88 or CVCC 1515 or UB1005

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram- E. coli ATCC25922 or K88 or CVCC 1515 or UB1005 (MIC 0.5-4 uM), B. pyocyaneum ATCC 27853 (MIC 16 uM), S. typhimurium ATCC 14028 (MIC 8 uM), Gram+ S. aur

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µM

Target

Target Organism B. pyocyaneum ATCC 27853

Source & Reference

Database Source NA

Other

Evidence Text

active against Gram- E. coli ATCC25922 or K88 or CVCC 1515 or UB1005 (MIC 0.5-4 uM), B. pyocyaneum ATCC 27853 (MIC 16 uM), S. typhimurium ATCC 14028 (MIC 8 uM), Gram+ S. aureus ATCC 29213 (MIC 8 uM) and S. epide

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism S. typhimurium ATCC 14028

Source & Reference

Database Source NA

Other

Evidence Text

25922 or K88 or CVCC 1515 or UB1005 (MIC 0.5-4 uM), B. pyocyaneum ATCC 27853 (MIC 16 uM), S. typhimurium ATCC 14028 (MIC 8 uM), Gram+ S. aureus ATCC 29213 (MIC 8 uM) and S. epidermidis ATCC 12228 (MIC 8 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Staphylococcus aureus ATCC 29213

Source & Reference

Database Source NA

Other

Evidence Text

-4 uM), B. pyocyaneum ATCC 27853 (MIC 16 uM), S. typhimurium ATCC 14028 (MIC 8 uM), Gram+ S. aureus ATCC 29213 (MIC 8 uM) and S. epidermidis ATCC 12228 (MIC 8 uM).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8 µM

Target

Target Organism Staphylococcus epidermidis ATCC 12228

Source & Reference

Database Source NA

Other

Evidence Text

C 16 uM), S. typhimurium ATCC 14028 (MIC 8 uM), Gram+ S. aureus ATCC 29213 (MIC 8 uM) and S. epidermidis ATCC 12228 (MIC 8 uM).

Evidence 6 Activity

Activity

Activity Endpoint 5% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 256 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

5% Hemolysis | 256 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Effect of terminal arrangement of tryptophan on biological activity of symmetric ?-helix-forming peptides. | Chem Biol Drug Des | 2019