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Peptide record

TPDB12671

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12671
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb dbAMP 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLKALWNVAKKVF
Physicochemical Analysis
C79H122N18O15
RDCEQGHIMPSTY
K
1563.95
10.84
3
0
9
+3
-2.04
0.700
120.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
351.67
1
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
3
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 3 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
13
C79H122N18O15
1563.95
10.84
+3
-2.04
0.700
Evidence Records 2 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
3.1 µM
Hemolytic Cytotoxic
<5% Hemolysis | 3.1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1. | Eur J Pharm Sci | 2019
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
40 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31181304] 40% hemolysis at 12.5 µmol/L, 70% hemolysis at 25 µmol/L, 80% hemolysis at 50 µmol/L against human red blood cells | Cytotoxicity: [Ref.31181304] ①The cell viability of MCF-7 cells induced by [Lys3][Lys11]-VmCT1-NH2 is 95%, 100%, 80%, 80%, 55%, 45%, 20% and 20% at peptide concentrations of 0.8, 1.6, 3.1, 12.5, 25, 50 and 100 µM. ②The cell viability of MCF-10A cells induced by [Lys3][Lys11]-VmCT1-NH2 is 120%, 120%, 90%, 100%, 120% and 95% at peptide concentrations of 0.8, 1.6, 3.1, 6.3, 12.5 and 25 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Pharm Sci. 2019 Jun 7 136:104952. doi: 10.1016/j.ejps.2019.06.006.