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Peptide record

TPDB12652

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12652
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia ToxinPred 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
KKWRKWLKALAKK
Physicochemical Analysis
C82H138N24O14
NDCEQGHIMFPSTYV
K
1684.15
11.90
7
0
6
+7
1.59
-1.423
75.38
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11000
653.15
0
Residue Composition
number
2
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
6
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
13
C82H138N24O14
1684.15
11.90
+7
1.59
-1.423
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

active against E. coli ATCC 25922 (MIC 12.5 ug/ml), S. aureus ATCC 25923 or ATCC 29213 (MIC 50->50 ug/ml), S. aureus ATCC 19636 (MIC 6.3 ug/
Evidence 2 Activity

Activity

MIC
Antibacterial
50->50 µg/mL

Target

Staphylococcus aureus ATCC 25923 or ATCC 29213

Source & Reference

NA

Other

active against E. coli ATCC 25922 (MIC 12.5 ug/ml), S. aureus ATCC 25923 or ATCC 29213 (MIC 50->50 ug/ml), S. aureus ATCC 19636 (MIC 6.3 ug/ml), P. aeruginosa Migula ATCC 27853 or 9027 (MIC 25 ug
Evidence 3 Activity

Activity

MIC
Antibacterial
6.3 µg/mL

Target

Staphylococcus aureus ATCC 19636

Source & Reference

NA

Other

coli ATCC 25922 (MIC 12.5 ug/ml), S. aureus ATCC 25923 or ATCC 29213 (MIC 50->50 ug/ml), S. aureus ATCC 19636 (MIC 6.3 ug/ml), P. aeruginosa Migula ATCC 27853 or 9027 (MIC 25 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Pseudomonas aeruginosa Migula ATCC 27853 or 9027

Source & Reference

NA

Other

aureus ATCC 25923 or ATCC 29213 (MIC 50->50 ug/ml), S. aureus ATCC 19636 (MIC 6.3 ug/ml), P. aeruginosa Migula ATCC 27853 or 9027 (MIC 25 ug/ml).
Evidence 5 Activity

Activity

<5% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational design of tryptophan-rich antimicrobial peptides with enhanced antimicrobial activities and specificities. | Chembiochem | 2010