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Peptide record

TPDB12650

Antibacterial Anticancer Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12650
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
FLGALWKALSHLL
Physicochemical Analysis
C73H113N17O15
RNDCEQIMPTYV
L
1468.81
10.10
2
0
9
+1
-4.03
1.246
165.38
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
374.45
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
0
I
5
L
1
K
0
M
1
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 5 K: 1 M: 0 F: 1 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
13
C73H113N17O15
1468.81
10.10
+1
-4.03
1.246
Evidence Records 7 records
Evidence 1 Activity

Activity

% Hemolysis
Hemolysis
15 %
Human erythrocytes: 15% Hemolysis=30 µM

Target

Human erythrocytes

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Arch Microbiol. 2012 Sep 194(9):769-78.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

IC50
Toxicity
49 µM
Cytotoxic
IC50 | 49 | µM | target cell: Normal breast cells MCF-10a

Target

Normal breast cells MCF-10a

Source & Reference

NA
DBAASP
Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria. | Arch Microbiol | 2012
Evidence 3 Activity

Activity

3% Hemolysis
Toxicity
7.5 µM
Hemolytic Cytotoxic
3% Hemolysis | 7.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria. | Arch Microbiol | 2012
Evidence 4 Activity

Activity

8% Hemolysis
Toxicity
15 µM
Hemolytic Cytotoxic
8% Hemolysis | 15 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria. | Arch Microbiol | 2012
Evidence 5 Activity

Activity

15% Hemolysis
Toxicity
30 µM
Hemolytic Cytotoxic
15% Hemolysis | 30 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria. | Arch Microbiol | 2012
Evidence 6 Activity

Activity

IC50
Toxicity
49 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 15% Hemolysis=30 µM | Cytotoxicity: MCF-10A: IC50=49 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Arch Microbiol. 2012 Sep 194(9):769-78.
Evidence 7 Hemolysis

Activity

15 %
% Hemolysis
Human erythrocytes: 15% Hemolysis=30 µM
Hemolysis

Target

Human erythrocytes

Source & Reference

PD_Hemolysis
Arch Microbiol. 2012 Sep 194(9):769-78.
DRAMP4
PD_Hemolysis