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Peptide record

TPDB12649

Antibacterial Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12649
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GLFAIIKKIAESF
Physicochemical Analysis
C70H113N15O17
RNDCQHMPTWYV
I
1436.76
9.88
2
1
8
+1
0.05
1.077
135.38
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
1
E
0
Q
1
G
0
H
3
I
1
L
2
K
0
M
2
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 3 L: 1 K: 2 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C70H113N15O17
1436.76
9.88
+1
0.05
1.077
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus ATCC 25923 (MIC 16 ug/ml), E. faecalis PCM 2673 (MIC 32 ug/ml), E. coli ATCC 25922 (MIC 8 ug/ml), P. aeruginosa ATC
Evidence 2 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

Enterococcus faecalis PCM 2673

Source & Reference

dbAMP

Other

Active against S. aureus ATCC 25923 (MIC 16 ug/ml), E. faecalis PCM 2673 (MIC 32 ug/ml), E. coli ATCC 25922 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 64 ug/ml), C. albicans AT
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

Active against S. aureus ATCC 25923 (MIC 16 ug/ml), E. faecalis PCM 2673 (MIC 32 ug/ml), E. coli ATCC 25922 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 64 ug/ml), C. albicans ATCC 10231 (MIC 64 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP

Other

23 (MIC 16 ug/ml), E. faecalis PCM 2673 (MIC 32 ug/ml), E. coli ATCC 25922 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 64 ug/ml), C. albicans ATCC 10231 (MIC 64 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP

Other

(MIC 32 ug/ml), E. coli ATCC 25922 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 64 ug/ml), C. albicans ATCC 10231 (MIC 64 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

Staphylococcus aureus ATCC 25923

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus ATCC 25923 (MIC 16 ug/ml), E. faecalis PCM 2673 (MIC 32 ug/ml), E. coli ATCC 25922 (MIC 8 ug/ml), P. aeruginosa ATC
Evidence 7 Activity

Activity

MIC
Antifungal
32 µg/mL

Target

Enterococcus faecalis PCM 2673

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC 25923 (MIC 16 ug/ml), E. faecalis PCM 2673 (MIC 32 ug/ml), E. coli ATCC 25922 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 64 ug/ml), C. albicans AT
Evidence 8 Activity

Activity

MIC
Antifungal
8 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against S. aureus ATCC 25923 (MIC 16 ug/ml), E. faecalis PCM 2673 (MIC 32 ug/ml), E. coli ATCC 25922 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 64 ug/ml), C. albicans ATCC 10231 (MIC 64 ug/ml).
Evidence 9 Activity

Activity

MIC
Antifungal
64 µg/mL

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

dbAMP CAFPdb Antifungipept

Other

23 (MIC 16 ug/ml), E. faecalis PCM 2673 (MIC 32 ug/ml), E. coli ATCC 25922 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 64 ug/ml), C. albicans ATCC 10231 (MIC 64 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
64 µg/mL

Target

Candida albicans ATCC 10231

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 32 ug/ml), E. coli ATCC 25922 (MIC 8 ug/ml), P. aeruginosa ATCC 9027 (MIC 64 ug/ml), C. albicans ATCC 10231 (MIC 64 ug/ml).
Evidence 11 Activity

Activity

61% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
61% Hemolysis | 256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine Scanning Studies of the Antimicrobial Peptide Aurein 1.2 | Probiotics Antimicrob Proteins | 2019
Evidence 12 Activity

Activity

23.2% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
23.2% Hemolysis | 128 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine Scanning Studies of the Antimicrobial Peptide Aurein 1.2 | Probiotics Antimicrob Proteins | 2019
Evidence 13 Activity

Activity

6.6% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
6.6% Hemolysis | 64 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine Scanning Studies of the Antimicrobial Peptide Aurein 1.2 | Probiotics Antimicrob Proteins | 2019
Evidence 14 Activity

Activity

1.5% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
1.5% Hemolysis | 32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine Scanning Studies of the Antimicrobial Peptide Aurein 1.2 | Probiotics Antimicrob Proteins | 2019
Evidence 15 Activity

Activity

0.3% Hemolysis
Toxicity
16 µg/mL
Hemolytic Cytotoxic
0.3% Hemolysis | 16 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Alanine Scanning Studies of the Antimicrobial Peptide Aurein 1.2 | Probiotics Antimicrob Proteins | 2019