Back to search

Peptide record

TPDB12645

Antibacterial Anticancer Antifungal Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12645
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
KKWRKWLKWLAKK
Physicochemical Analysis
C90H143N25O14
NDCEQGHIMFPSTYV
K
1799.28
11.90
7
0
6
+7
-0.09
-1.631
67.69
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
16500
917.03
0
Residue Composition
number
1
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
6
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
13
C90H143N25O14
1799.28
11.90
+7
-0.09
-1.631
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.13 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against E. coli ATCC 25922 (MIC 3.13 ug/ml), P. aeruginosa ATCC 27853 (MIC 3.13 ug/ml), A. baumannii 14B0091 or 14B0097 or 14B00100 (
Evidence 2 Activity

Activity

MIC
Antibacterial
3.13 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

active against E. coli ATCC 25922 (MIC 3.13 ug/ml), P. aeruginosa ATCC 27853 (MIC 3.13 ug/ml), A. baumannii 14B0091 or 14B0097 or 14B00100 (MIC 1.56 ug/ml), and S. aureus ATCC 25923 o
Evidence 3 Activity

Activity

MIC
Antibacterial
1.56 µg/mL

Target

A. baumannii 14B0091 or 14B0097 or 14B00100

Source & Reference

dbAMP

Other

e against E. coli ATCC 25922 (MIC 3.13 ug/ml), P. aeruginosa ATCC 27853 (MIC 3.13 ug/ml), A. baumannii 14B0091 or 14B0097 or 14B00100 (MIC 1.56 ug/ml), and S. aureus ATCC 25923 or 6538 (MIC 3.13-6.25 ug/ml), S. aureus 33591 or 33592 or 3359
Evidence 4 Activity

Activity

MIC
Antibacterial
3.13-6.25 µg/mL

Target

Staphylococcus aureus ATCC 25923 or 6538

Source & Reference

dbAMP

Other

27853 (MIC 3.13 ug/ml), A. baumannii 14B0091 or 14B0097 or 14B00100 (MIC 1.56 ug/ml), and S. aureus ATCC 25923 or 6538 (MIC 3.13-6.25 ug/ml), S. aureus 33591 or 33592 or 33593 MRSA (MIC 12.5 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
12.5 µg/mL

Target

Staphylococcus aureus 33591 or 33592 or 33593 MRSA

Source & Reference

dbAMP

Other

097 or 14B00100 (MIC 1.56 ug/ml), and S. aureus ATCC 25923 or 6538 (MIC 3.13-6.25 ug/ml), S. aureus 33591 or 33592 or 33593 MRSA (MIC 12.5 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
3.13 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against E. coli ATCC 25922 (MIC 3.13 ug/ml), P. aeruginosa ATCC 27853 (MIC 3.13 ug/ml), A. baumannii 14B0091 or 14B0097 or 14B00100 (
Evidence 7 Activity

Activity

MIC
Antifungal
3.13 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

active against E. coli ATCC 25922 (MIC 3.13 ug/ml), P. aeruginosa ATCC 27853 (MIC 3.13 ug/ml), A. baumannii 14B0091 or 14B0097 or 14B00100 (MIC 1.56 ug/ml), and S. aureus ATCC 25923 o
Evidence 8 Activity

Activity

MIC
Antifungal
1.56 µg/mL

Target

A. baumannii 14B0091 or 14B0097 or 14B00100

Source & Reference

dbAMP CAFPdb Antifungipept

Other

e against E. coli ATCC 25922 (MIC 3.13 ug/ml), P. aeruginosa ATCC 27853 (MIC 3.13 ug/ml), A. baumannii 14B0091 or 14B0097 or 14B00100 (MIC 1.56 ug/ml), and S. aureus ATCC 25923 or 6538 (MIC 3.13-6.25 ug/ml), S. aureus 33591 or 33592 or 3359
Evidence 9 Activity

Activity

MIC
Antifungal
3.13-6.25 µg/mL

Target

Staphylococcus aureus ATCC 25923 or 6538

Source & Reference

dbAMP CAFPdb Antifungipept

Other

27853 (MIC 3.13 ug/ml), A. baumannii 14B0091 or 14B0097 or 14B00100 (MIC 1.56 ug/ml), and S. aureus ATCC 25923 or 6538 (MIC 3.13-6.25 ug/ml), S. aureus 33591 or 33592 or 33593 MRSA (MIC 12.5 ug/ml).
Evidence 10 Activity

Activity

MIC
Antifungal
12.5 µg/mL

Target

Staphylococcus aureus 33591 or 33592 or 33593 MRSA

Source & Reference

dbAMP CAFPdb Antifungipept

Other

097 or 14B00100 (MIC 1.56 ug/ml), and S. aureus ATCC 25923 or 6538 (MIC 3.13-6.25 ug/ml), S. aureus 33591 or 33592 or 33593 MRSA (MIC 12.5 ug/ml).
Evidence 11 Activity

Activity

<10% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
<10% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational design of tryptophan-rich antimicrobial peptides with enhanced antimicrobial activities and specificities. | Chembiochem | 2010
Evidence 12 Activity

Activity

18% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
18% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational design of tryptophan-rich antimicrobial peptides with enhanced antimicrobial activities and specificities. | Chembiochem | 2010
Evidence 13 Activity

Activity

IC50
Toxicity
20±13 µM
Cytotoxic
IC50 | 20±13 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Repurposing azithromycin and rifampicin against Gram-negative pathogens by combination with peptide potentiators. | Int J Antimicrob Agents | 2019
Evidence 14 Activity

Activity

10% Hemolysis
Toxicity
30 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 30 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Sequence Permutation Generated Lysine and Tryptophan-Rich Antimicrobial Peptides with Enhanced Therapeutic Index | Antibiotics (Basel) | 2025
Evidence 15 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Antimicrob Agents. 2019 Jun 53(6):868-872.