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Peptide record

TPDB12640

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12640
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
LLKAAAKAAAKLL
Physicochemical Analysis
C60H112N16O14
RNDCEQGHIMFPSTWYV
A
1281.65
10.84
3
0
10
+3
-0.29
1.100
166.15
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
6
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
4
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 6 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 4 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C60H112N16O14
1281.65
10.84
+3
-0.29
1.100
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2-32 µM

Target

Escherichia coli ATCC25922 or K88 or CVCC 1515 or UB1005

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram- E. coli ATCC25922 or K88 or CVCC 1515 or UB1005 (MIC 2-32 uM), B.pyocyaneum ATCC 27853 (MIC > 128 uM), S.typhimurium ATCC 14028 (MIC 128 uM), S.pulloru
Evidence 2 Activity

Activity

MIC
Antibacterial
128 µM

Target

S.typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP

Other

5922 or K88 or CVCC 1515 or UB1005 (MIC 2-32 uM), B.pyocyaneum ATCC 27853 (MIC > 128 uM), S.typhimurium ATCC 14028 (MIC 128 uM), S.pullorum C79–13 (MIC > 128 uM), Gram+ S.aureus ATCC 29213 (MIC > 128 uM), S.epidermidi
Evidence 3 Activity

Activity

MIC
Antibacterial
128 µM

Target

S.epidermidis ATCC 12228

Source & Reference

dbAMP DRAMP

Other

(MIC 128 uM), S.pullorum C79–13 (MIC > 128 uM), Gram+ S.aureus ATCC 29213 (MIC > 128 uM), S.epidermidis ATCC 12228 (MIC 128 uM), S. faecalis ATCC 29212 (MIC 16 uM), and B. subtilis CMCC 63501 (MIC 32 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
16 µM

Target

S. faecalis ATCC 29212

Source & Reference

dbAMP DRAMP

Other

128 uM), Gram+ S.aureus ATCC 29213 (MIC > 128 uM), S.epidermidis ATCC 12228 (MIC 128 uM), S. faecalis ATCC 29212 (MIC 16 uM), and B. subtilis CMCC 63501 (MIC 32 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
32 µM

Target

B. subtilis CMCC 63501

Source & Reference

dbAMP DRAMP

Other

> 128 uM), S.epidermidis ATCC 12228 (MIC 128 uM), S. faecalis ATCC 29212 (MIC 16 uM), and B. subtilis CMCC 63501 (MIC 32 uM).
Evidence 6 Activity

Activity

5% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
5% Hemolysis | >256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational design of mirror-like peptides with alanine regulation. | Amino Acids | 2016
Evidence 7 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Rational design of mirror-like peptides with alanine regulation. | Amino Acids | 2016
Evidence 8 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.26385363] MHC5>256 µM against human red blood cells | Cytotoxicity: [Ref.26385363] The cell viability of HEK293 cells induced by KL4A6 is 107.8%, 108.3%, 104.4%, 104.7%, 105.6%, 100%, 94.4% and 96.7% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 µM. The cell viability of HEK293 cells induced by control Meli

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2016 Feb 48(2):403-17. doi: 10.1007/s00726-015-2094-y.