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Peptide record

TPDB12637

Antibacterial Anticancer Cell-penetrating Peptides Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12637
Antibacterial Anticancer Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 dbAMP DRAMP Peptipedia CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KIWFQNRRMKWKK
Physicochemical Analysis
C87H137N27O16S1
ADCEGHLPSTYV
K
1849.28
12.44
6
0
5
+6
1.21
-1.862
30.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
11000
594.83
2
Residue Composition
number
0
A
2
R
1
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
13
C87H137N27O16S1
1849.28
12.44
+6
1.21
-1.862
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
50% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial and cell-penetrating properties of penetratin analogs: effect of sequence and secondary structure. | Biochim Biophys Acta | 2013
Evidence 2 Activity

Activity

HC50
Toxicity
128 µM
Hemolytic
Hemolytic_activity: [Ref.23085001] HC50>128 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2013 Feb 1828(2):223-232. doi: 10.1016/j.bbamem.2012.10.010.