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Peptide record

TPDB12630

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12630
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
NKVKEWWKWLKKL
Physicochemical Analysis
C89H136N22O17
ARDCQGHIMFPSTY
K
1786.20
10.71
5
1
6
+4
0.79
-1.338
82.31
Mammalian: 1.4 hour Yeast: 3 min E.coli: >10 hour
16500
923.75
1
Residue Composition
number
0
A
0
R
1
N
0
D
0
C
1
E
0
Q
0
G
0
H
0
I
2
L
5
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 1
Chemical Descriptors
13
C89H136N22O17
1786.20
10.71
+4
0.79
-1.338
Evidence Records 5 records
Evidence 1 Activity

Activity

IC50
Toxicity
83.7 µM
Cytotoxic
IC50 | 83.7 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Design and Engineering of Antimicrobial Peptides Based on LPcin-YK3, an Antimicrobial Peptide Derivative from Bovine Milk. | J Microbiol Biotechnol | 2018
Evidence 2 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Human Lung Fibroblasts

Target

Human Lung Fibroblasts

Source & Reference

NA
DBAASP
Design and Engineering of Antimicrobial Peptides Based on LPcin-YK3, an Antimicrobial Peptide Derivative from Bovine Milk. | J Microbiol Biotechnol | 2018
Evidence 3 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Mouse fibroblasts L929

Target

Mouse fibroblasts L929

Source & Reference

NA
DBAASP
Design and Engineering of Antimicrobial Peptides Based on LPcin-YK3, an Antimicrobial Peptide Derivative from Bovine Milk. | J Microbiol Biotechnol | 2018
Evidence 4 Activity

Activity

IC50
Toxicity
96.6 µM
Cytotoxic
IC50 | 96.6 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Design and Engineering of Antimicrobial Peptides Based on LPcin-YK3, an Antimicrobial Peptide Derivative from Bovine Milk. | J Microbiol Biotechnol | 2018
Evidence 5 Activity

Activity

IC50
Toxicity
86.8 µM
Cytotoxic
IC50 | 86.8 | µM | target cell: Chinese hamster ovary cells CHO-K1

Target

Chinese hamster ovary cells CHO-K1

Source & Reference

NA
DBAASP
Design and Engineering of Antimicrobial Peptides Based on LPcin-YK3, an Antimicrobial Peptide Derivative from Bovine Milk. | J Microbiol Biotechnol | 2018