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Peptide record

TPDB12629

PTP-7a Antibacterial Anticancer Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12629
PTP-7a
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.
Sequence
FLGALFHALSKLL
Physicochemical Analysis
C71H112N16O15
RNDCEQIMPTWYV
L
1429.77
10.10
2
0
9
+1
-3.31
1.531
165.38
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
0
I
5
L
1
K
0
M
2
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 5 K: 1 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C71H112N16O15
1429.77
10.10
+1
-3.31
1.531
Free
L
Linear
Free
Anticancer
Synthetic peptide
Evidence Records 6 records
Evidence 1 Activity

Activity

IC50
IC50 =28 µM
Anticancer
28 µM

Target

Lung Cancer
A-549
Lung

Assay & Model

MTT/MTS assay

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2012

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

IC50
Toxicity
32 µM
Cytotoxic
IC50 | 32 | µM | target cell: Normal breast cells MCF-10a

Target

Normal breast cells MCF-10a

Source & Reference

NA
DBAASP
Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria. | Arch Microbiol | 2012
Evidence 3 Activity

Activity

0.5% Hemolysis
Toxicity
7.5 µM
Hemolytic Cytotoxic
0.5% Hemolysis | 7.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria. | Arch Microbiol | 2012
Evidence 4 Activity

Activity

2.5% Hemolysis
Toxicity
15 µM
Hemolytic Cytotoxic
2.5% Hemolysis | 15 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria. | Arch Microbiol | 2012
Evidence 5 Activity

Activity

6.8% Hemolysis
Toxicity
30 µM
Hemolytic Cytotoxic
6.8% Hemolysis | 30 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Activity and selectivity of histidine-containing lytic peptides to antibiotic-resistant bacteria. | Arch Microbiol | 2012
Evidence 6 Activity

Activity

IC50
Toxicity
32 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 6.8% Hemolysis=30 µM | Cytotoxicity: MCF-10A: IC50=32 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biomacromolecules. 2012 Oct 8 13(10):3327-33.