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Peptide record

TPDB12624

Antibacterial Antifungal Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12624
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AFP-GFuse Antifungipept CAFPdb PD_Hemolysis
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLGALWNVLKSVF
Physicochemical Analysis
C75H112N16O16
RDCEQHIMPTY
L
1493.81
10.10
1
0
9
+1
-4.27
1.362
142.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
368.19
2
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
3
L
1
K
0
M
2
F
0
P
1
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 3 K: 1 M: 0 F: 2 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
13
C75H112N16O16
1493.81
10.10
+1
-4.27
1.362
Evidence Records 4 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
1.6 µM
Hemolytic Cytotoxic
0% Hemolysis | 1.6 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens. | Bioorg Chem | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens. | Bioorg Chem | 2019
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
20 %
Hemolytic
Hemolytic_activity: [Ref.31212183] 20% hemolysis at 3.1 µmol/L, 70% hemolysis at 25 µmol/L, 100% hemolysis at 100 µmol/L for human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Bioorg Chem. 2019 Jun 8 90:103038. doi: 10.1016/j.bioorg.2019.103038.
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis