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Peptide record

TPDB12614

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12614
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 13-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GLFKIIKKIWKSF
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C82H130N18O15
ARNDCEQHMPTYV
K
1608.05
11.00
4
0
7
+4
-0.25
0.400
120.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
3.42
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
1
L
4
K
0
M
2
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 1 K: 4 M: 0 F: 2 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
13 reviewed residue count
C82H130N18O15 sequence-only estimate (linear, free termini)
1608.05 sequence-only estimate (linear, free termini)
11.00 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
-0.25 sequence-only estimate (linear, free termini)
0.400 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
25 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 25 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and characterization of new antimicrobial peptides derived from aurein 1.2 with enhanced antibacterial activity. | Biochimie | 2021
Evidence 2 Activity

Activity

43.86% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
43.86% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design and characterization of new antimicrobial peptides derived from aurein 1.2 with enhanced antibacterial activity. | Biochimie | 2021
Evidence 3 Activity

Activity

27.79% Killing
Toxicity
200 µg/mL
Cytotoxic
27.79% Killing | 200 | µg/mL | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Design and characterization of new antimicrobial peptides derived from aurein 1.2 with enhanced antibacterial activity. | Biochimie | 2021