Back to search

Peptide record

TPDB12607

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12607
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 13-aa standard-residue multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FKRHVQRIKDFLR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C80H131N27O17
ANCEGMPSTWY
R
1743.09
12.13
6
1
5
+4
4.23
-1.031
82.31
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
3
R
0
N
1
D
0
C
0
E
1
Q
0
G
1
H
1
I
1
L
2
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 1 I: 1 L: 1 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
13 reviewed residue count
C80H131N27O17 sequence-only estimate (linear, free termini)
1743.09 sequence-only estimate (linear, free termini)
12.13 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
4.23 sequence-only estimate (linear, free termini)
-1.031 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
>1280 µM
Hemolytic Cytotoxic
10% Hemolysis | >1280 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Disruption of interactions between hydrophobic residues on nonpolar faces is a key determinant in decreasing hemolysis and increasing antimicrobial activities of α-helical amphipathic peptides. | ChemMedChem | 2013
Evidence 2 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.23894079] MHC10>1280 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
ChemMedChem. 2013 Oct 8(10):1638-42. doi: 10.1002/cmdc.201300264.