Back to search

Peptide record

TPDB12600

Antibacterial Antifungal Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12600
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb PD_Hemolysis
standard
No
A 13-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLGALWNVAKSYF
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C76H106N16O17
RDCEQHIMPT
ALF
1515.77
9.74
1
0
9
+1
-0.85
0.785
97.69
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
6990
4.61
3
Residue Composition
number
2
A
0
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
2
L
1
K
0
M
2
F
0
P
1
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 2 K: 1 M: 0 F: 2 P: 0 S: 1 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
13 reviewed residue count
C76H106N16O17 sequence-only estimate (linear, free termini)
1515.77 sequence-only estimate (linear, free termini)
9.74 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
-0.85 sequence-only estimate (linear, free termini)
0.785 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
6.3 µM
Hemolytic Cytotoxic
0% Hemolysis | 6.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens. | Bioorg Chem | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Repurposing the scorpion venom peptide VmCT1 into an active peptide against Gram-negative ESKAPE pathogens. | Bioorg Chem | 2019
Evidence 3 Activity

Activity

% Hemolysis
Toxicity
25 %
Hemolytic
Hemolytic_activity: [Ref.31212183] 25% hemolysis at 12.5 µmol/L, 60% hemolysis at 25 µmol/L, 85% hemolysis at 50 µmol/L, 100% hemolysis at 100 µmol/L for human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Bioorg Chem. 2019 Jun 8 90:103038. doi: 10.1016/j.bioorg.2019.103038.
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis