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Peptide record

TPDB12594

Antibacterial Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12594
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 13-aa standard-residue multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
GLLSLLSLAGKLL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C61H112N14O16
RNDCEQHIMFPTWYV
L
1297.64
10.10
1
0
8
+1
-1.98
1.700
217.69
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
2
G
0
H
0
I
7
L
1
K
0
M
0
F
0
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 7 K: 1 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13 reviewed residue count
C61H112N14O16 sequence-only estimate (linear, free termini)
1297.64 sequence-only estimate (linear, free termini)
10.10 sequence-only estimate (linear, free termini)
+1 sequence-only estimate (linear, free termini)
-1.98 sequence-only estimate (linear, free termini)
1.700 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.78 µM

Target

Staphylococcus aureus USA300

Source & Reference

NA

Other

Active against S. aureus USA300 (MIC 0.78 uM), P. aeruginosa PAO1 (MIC 12.5 uM), E. coli ATCC 25922 (MIC 3.1 uM), and K. pneumonia ATCC
Evidence 2 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Pseudomonas aeruginosa PAO1

Source & Reference

NA

Other

Active against S. aureus USA300 (MIC 0.78 uM), P. aeruginosa PAO1 (MIC 12.5 uM), E. coli ATCC 25922 (MIC 3.1 uM), and K. pneumonia ATCC13883 (MIC 3.1 uM).
Evidence 3 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

Active against S. aureus USA300 (MIC 0.78 uM), P. aeruginosa PAO1 (MIC 12.5 uM), E. coli ATCC 25922 (MIC 3.1 uM), and K. pneumonia ATCC13883 (MIC 3.1 uM).
Evidence 4 Activity

Activity

MIC
Antibacterial
3.1 µM

Target

K. pneumonia ATCC13883

Source & Reference

NA

Other

300 (MIC 0.78 uM), P. aeruginosa PAO1 (MIC 12.5 uM), E. coli ATCC 25922 (MIC 3.1 uM), and K. pneumonia ATCC13883 (MIC 3.1 uM).
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
14 µM
Hemolytic Cytotoxic
50% Hemolysis | 14 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Low cationicity is important for systemic in vivo efficacy of database-derived peptides against drug-resistant Gram-positive pathogens. | Proc Natl Acad Sci U S A | 2019
Evidence 6 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis