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Peptide record

TPDB12591

Antibacterial Anticancer Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12591
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
ILPWKWKWTPWRR
Physicochemical Analysis
C94H133N25O15
ANDCEQGHMFSYV
W
1853.25
12.42
4
0
6
+4
-3.63
-1.231
60.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
22000
1187.10
1
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
2
K
0
M
0
F
2
P
0
S
1
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 2 M: 0 F: 0 P: 2 S: 0 T: 1 W: 4 Y: 0 V: 0
Chemical Descriptors
13
C94H133N25O15
1853.25
12.42
+4
-3.63
-1.231
Evidence Records 3 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
5% Hemolysis | 100 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Design of therapeutically improved analogue of the antimicrobial peptide, indolicidin, using a glycosylation strategy. | Amino Acids | 2019
Evidence 2 Activity

Activity

25% Hemolysis
Toxicity
400 µM
Hemolytic Cytotoxic
25% Hemolysis | 400 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Design of therapeutically improved analogue of the antimicrobial peptide, indolicidin, using a glycosylation strategy. | Amino Acids | 2019
Evidence 3 Activity

Activity

LD50
Toxicity
25 µM
Cytotoxic
LD50 | 25 | µM | target cell: Murine macrophage cells J774A.1

Target

Murine macrophage cells J774A.1

Source & Reference

NA
DBAASP
Design of therapeutically improved analogue of the antimicrobial peptide, indolicidin, using a glycosylation strategy. | Amino Acids | 2019