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Peptide record

TPDB12585

Antibacterial Antifungal Antiviral Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB12585
Antibacterial Antifungal Antiviral Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept AI4AVP dbAMP 3.0
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
ATCYCRTGRCATR
Physicochemical Analysis
C56H96N22O18S3
NDEQHILKMFPSWV
RCT
1461.70
9.19
3
0
3
+3
0.86
-0.477
15.38
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
1615
110.49
7
Residue Composition
number
2
A
3
R
0
N
0
D
3
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
3
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 0 C: 3 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 3 W: 0 Y: 1 V: 0
Chemical Descriptors
13
C56H96N22O18S3
1461.70
9.19
+3
0.86
-0.477
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
>100 µM

Target

A.baumannii 4-MRGN

Source & Reference

NA

Other

. rhamnosus, L. salivarius, and S. solivarius salivarius. However, it is inactive against A.baumannii 4-MRGN (MIC >100 uM), K.pneumoniae 3-MRGN (activity not detected), P.aeruginosa ATCC 27853 (MIC >100 uM), E.fa
Evidence 2 Activity

Activity

MIC
Antibacterial
>100 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

NA

Other

ve against A.baumannii 4-MRGN (MIC >100 uM), K.pneumoniae 3-MRGN (activity not detected), P.aeruginosa ATCC 27853 (MIC >100 uM), E.faecium 475747 (activity not detected), and S.aureus USA300 (activity not detected). T
Evidence 3 Activity

Activity

MIC
Antifungal
>100 µM

Target

A.baumannii 4-MRGN

Source & Reference

Antifungipept

Other

. rhamnosus, L. salivarius, and S. solivarius salivarius. However, it is inactive against A.baumannii 4-MRGN (MIC >100 uM), K.pneumoniae 3-MRGN (activity not detected), P.aeruginosa ATCC 27853 (MIC >100 uM), E.fa
Evidence 4 Activity

Activity

MIC
Antifungal
>100 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

Antifungipept

Other

ve against A.baumannii 4-MRGN (MIC >100 uM), K.pneumoniae 3-MRGN (activity not detected), P.aeruginosa ATCC 27853 (MIC >100 uM), E.faecium 475747 (activity not detected), and S.aureus USA300 (activity not detected). T
Evidence 5 Activity

Activity

MIC
Antiviral
>100 µM

Target

A.baumannii 4-MRGN

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
. rhamnosus, L. salivarius, and S. solivarius salivarius. However, it is inactive against A.baumannii 4-MRGN (MIC >100 uM), K.pneumoniae 3-MRGN (activity not detected), P.aeruginosa ATCC 27853 (MIC >100 uM), E.fa
Evidence 6 Activity

Activity

MIC
Antiviral
>100 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

dbAMP 3.0

Other

ve against A.baumannii 4-MRGN (MIC >100 uM), K.pneumoniae 3-MRGN (activity not detected), P.aeruginosa ATCC 27853 (MIC >100 uM), E.faecium 475747 (activity not detected), and S.aureus USA300 (activity not detected). T
Evidence 7 Activity

Activity

50% Cytotoxicity
Toxicity
127 µM
Cytotoxic
50% Cytotoxicity | 127 | µM | target cell: Human retinal epithelial cells ARPE-19

Target

Human retinal epithelial cells ARPE-19

Source & Reference

NA
DBAASP
The Human ?-Defensin-Derived Peptide HD5(1-9) Inhibits Cellular Attachment and Entry of Human Cytomegalovirus | Antiviral Res | 2020