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Peptide record

TPDB12562

Antibacterial Anticancer Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB12562
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RRLRKKTRKRLK
Physicochemical Analysis
C70H139N31O14
ANDCEQGHIMFPSWYV
R
1639.07
13.01
9
0
2
+9
7.03
-2.600
65.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
1
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
4
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 4 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C70H139N31O14
1639.07
13.01
+9
7.03
-2.600
Evidence Records 2 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
>128 µM
Hemolytic Cytotoxic
5% Hemolysis | >128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of Trp-Rich Dodecapeptides with Broad-Spectrum Antimicrobial Potency and Membrane-Disruptive Mechanism. | J Med Chem | 2019
Evidence 2 Activity

Activity

MHC
Toxicity
128 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.31276398] MHC>128µM. The minimum hemolytic concentration (MHC) is measured as the lowest concentration of the peptides that caused 5% hemolysis of human red blood cells (hRBCs). | Cytotoxicity: [Ref.31276398] The cell viability of the murine macrophage cell line RAW264.7 induced by RK12 is 91.7%, 96.2%, 95.2%, 95.3%, 96.2%, 94.7%, 98.8% and 99.3% at peptide concentrations of 1, 2, 4, 8, 16, 32, 64 and 128 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2019 Aug 8 62(15):6941-6957. doi: 10.1021/acs.jmedchem.9b00288.