TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB12559

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

AntiBP3 Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 12-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and Antifungipept, with an available 3D structural model.

Sequence

FRIMRILRVLKL

FASTA

>TPDB12559|Antibacterial;Antifungal;Toxicity|length=12
FRIMRILRVLKL

Formula C73H132N22O13S1

Absent Amino Acids ANDCEQGHPSTWY

Common Amino Acids RL

Mass 1558.05

PI 12.71

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +4

Boman Index -0.17

Hydrophobicity 0.992

Aliphatic Index 186.67

Half Life

Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 0

number

0

A

3

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

2

I

3

L

1

K

1

M

1

F

0

P

0

S

0

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 3 K: 1 M: 1 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1

Length

12

Formula

C73H132N22O13S1

Mass

1558.05

PI

12.71

Net Charge

+4

Boman Index

-0.17

Hydrophobicity

0.992

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10.3 µM

Target

Target Organism B. subtilis 168 HT

Source & Reference

Database Source NA

Other

Evidence Text

Active against B. subtilis 168 HT (MIC 10.3 uM). E. coli MG1655 (MIC 10.3 uM), and C. trachomatis D/UW-3/Cx (MIC90 3.1 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 10.3 µM

Target

Target Organism Escherichia coli MG1655

Source & Reference

Database Source NA

Other

Evidence Text

Active against B. subtilis 168 HT (MIC 10.3 uM). E. coli MG1655 (MIC 10.3 uM), and C. trachomatis D/UW-3/Cx (MIC90 3.1 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10.3 µM

Target

Target Organism B. subtilis 168 HT

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against B. subtilis 168 HT (MIC 10.3 uM). E. coli MG1655 (MIC 10.3 uM), and C. trachomatis D/UW-3/Cx (MIC90 3.1 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 10.3 µM

Target

Target Organism Escherichia coli MG1655

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Active against B. subtilis 168 HT (MIC 10.3 uM). E. coli MG1655 (MIC 10.3 uM), and C. trachomatis D/UW-3/Cx (MIC90 3.1 uM).

Evidence 5 Activity

Activity

Activity Endpoint 15% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 100 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

15% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Medicinal leech antimicrobial peptides lacking toxicity represent a promising alternative strategy to combat antibiotic-resistant pathogens. | Eur J Med Chem | 2019