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Peptide record

TPDB12557

Antibacterial standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB12557
Antibacterial
Anti-infective peptides
AntiBP3 Peptipedia
standard
No
A 12-aa standard-residue antibacterial peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
GWWRRTVAKVRN
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C69H109N25O15
DCEQHILMFPSY
R
1528.78
12.71
4
0
5
+4
3.67
-1.133
56.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
7.20
2
Residue Composition
number
1
A
3
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
1
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 2
Chemical Descriptors
12 reviewed residue count
C69H109N25O15 sequence-only estimate (linear, free termini)
1528.78 sequence-only estimate (linear, free termini)
12.71 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
3.67 sequence-only estimate (linear, free termini)
-1.133 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.6 µM

Target

C. glutamicum ATCC 13032

Source & Reference

NA

Other

Active against C. glutamicum ATCC 13032 (MIC 1.6 uM), S.aureus ATCC 9144 (MIC 50 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC
Evidence 2 Activity

Activity

MIC
Antibacterial
50 µM

Target

S.aureus ATCC 9144

Source & Reference

NA

Other

Active against C. glutamicum ATCC 13032 (MIC 1.6 uM), S.aureus ATCC 9144 (MIC 50 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 6.3 uM). Antifungal:
Evidence 3 Activity

Activity

MIC
Antibacterial
6.3 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

NA

Other

Active against C. glutamicum ATCC 13032 (MIC 1.6 uM), S.aureus ATCC 9144 (MIC 50 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 6.3 uM). Antifungal: C. albicans (MIC 100 uM), A. pullulans
Evidence 4 Activity

Activity

MIC
Antibacterial
6.3 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

(MIC 1.6 uM), S.aureus ATCC 9144 (MIC 50 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 6.3 uM). Antifungal: C. albicans (MIC 100 uM), A. pullulans (MIC 12.5 uM), and Rhodotorula sp. (M
Evidence 5 Activity

Activity

MIC
Antibacterial
100 µM

Target

Candida albicans

Source & Reference

NA

Other

, P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 6.3 uM). Antifungal: C. albicans (MIC 100 uM), A. pullulans (MIC 12.5 uM), and Rhodotorula sp. (MIC 12.5 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

A. pullulans

Source & Reference

NA

Other

(MIC 6.3 uM), and E. coli ATCC 25922 (MIC 6.3 uM). Antifungal: C. albicans (MIC 100 uM), A. pullulans (MIC 12.5 uM), and Rhodotorula sp. (MIC 12.5 uM).