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Peptide record

TPDB12537

Antibacterial Antifungal Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB12537
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept PD_Hemolysis
standard
No
A 12-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
WKIFKLKLRMLW
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C84H132N20O13S1
ANDCEQGHPSTYV
LK
1662.16
11.73
4
0
8
+4
0.16
0.217
130.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
6.62
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
3
L
3
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 3 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
12 reviewed residue count
C84H132N20O13S1 sequence-only estimate (linear, free termini)
1662.16 sequence-only estimate (linear, free termini)
11.73 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
0.16 sequence-only estimate (linear, free termini)
0.217 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
38.5 µM

Target

B. subtilis 168 HT

Source & Reference

NA

Other

Active against B. subtilis 168 HT (MIC 38.5 uM). E. coli MG1655 (MIC 77 uM), and C. trachomatis D/UW-3/Cx (MIC90 50 uM). Note that whethe
Evidence 2 Activity

Activity

MIC
Antibacterial
77 µM

Target

Escherichia coli MG1655

Source & Reference

NA

Other

Active against B. subtilis 168 HT (MIC 38.5 uM). E. coli MG1655 (MIC 77 uM), and C. trachomatis D/UW-3/Cx (MIC90 50 uM). Note that whether this is a natural AMP enco
Evidence 3 Activity

Activity

MIC
Antifungal
38.5 µM

Target

B. subtilis 168 HT

Source & Reference

Antifungipept

Other

Active against B. subtilis 168 HT (MIC 38.5 uM). E. coli MG1655 (MIC 77 uM), and C. trachomatis D/UW-3/Cx (MIC90 50 uM). Note that whethe
Evidence 4 Activity

Activity

MIC
Antifungal
77 µM

Target

Escherichia coli MG1655

Source & Reference

Antifungipept

Other

Active against B. subtilis 168 HT (MIC 38.5 uM). E. coli MG1655 (MIC 77 uM), and C. trachomatis D/UW-3/Cx (MIC90 50 uM). Note that whether this is a natural AMP enco
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
6.25 µM
Hemolytic Cytotoxic
50% Hemolysis | 6.25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Medicinal leech antimicrobial peptides lacking toxicity represent a promising alternative strategy to combat antibiotic-resistant pathogens. | Eur J Med Chem | 2019
Evidence 6 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis