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Peptide record

TPDB12537

Antibacterial Antifungal Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB12537
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept PD_Hemolysis
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
WKIFKLKLRMLW
Physicochemical Analysis
C84H132N20O13S1
ANDCEQGHPSTYV
LK
1662.16
11.73
4
0
8
+4
-3.27
0.217
130.00
Mammalian: 2.8 hour Yeast: 3 min E.coli: 2 min
11000
661.79
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
3
L
3
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 3 K: 3 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
12
C84H132N20O13S1
1662.16
11.73
+4
-3.27
0.217
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
38.5 µM

Target

B. subtilis 168 HT

Source & Reference

NA

Other

Active against B. subtilis 168 HT (MIC 38.5 uM). E. coli MG1655 (MIC 77 uM), and C. trachomatis D/UW-3/Cx (MIC90 50 uM). Note that whethe
Evidence 2 Activity

Activity

MIC
Antibacterial
77 µM

Target

Escherichia coli MG1655

Source & Reference

NA

Other

Active against B. subtilis 168 HT (MIC 38.5 uM). E. coli MG1655 (MIC 77 uM), and C. trachomatis D/UW-3/Cx (MIC90 50 uM). Note that whether this is a natural AMP enco
Evidence 3 Activity

Activity

MIC
Antifungal
38.5 µM

Target

B. subtilis 168 HT

Source & Reference

Antifungipept

Other

Active against B. subtilis 168 HT (MIC 38.5 uM). E. coli MG1655 (MIC 77 uM), and C. trachomatis D/UW-3/Cx (MIC90 50 uM). Note that whethe
Evidence 4 Activity

Activity

MIC
Antifungal
77 µM

Target

Escherichia coli MG1655

Source & Reference

Antifungipept

Other

Active against B. subtilis 168 HT (MIC 38.5 uM). E. coli MG1655 (MIC 77 uM), and C. trachomatis D/UW-3/Cx (MIC90 50 uM). Note that whether this is a natural AMP enco
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
6.25 µM
Hemolytic Cytotoxic
50% Hemolysis | 6.25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Medicinal leech antimicrobial peptides lacking toxicity represent a promising alternative strategy to combat antibiotic-resistant pathogens. | Eur J Med Chem | 2019
Evidence 6 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis