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Peptide record

TPDB12520

Antibacterial Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB12520
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RLCRIWWIRWCR
Physicochemical Analysis
C81H123N27O13S2
ANDEQGHKMFPSTYV
R
1747.16
11.93
4
0
6
+4
-3.97
-0.242
97.50
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16625
951.54
2
Residue Composition
number
0
A
4
R
0
N
0
D
2
C
0
E
0
Q
0
G
0
H
2
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
12
C81H123N27O13S2
1747.16
11.93
+4
-3.97
-0.242
Evidence Records 2 records
Evidence 1 Activity

Activity

0.9% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0.9% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A significantly enhanced antibacterial spectrum of D-enantiomeric lipopeptide bactenecin. | Biochem Biophys Res Commun | 2019
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
0.9 %
Hemolytic
Hemolytic_activity: [Ref.31056261] 0.9% hemolysis at 100 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2019 Jun 25 514(2):497-502. doi: 10.1016/j.bbrc.2019.04.153. Epub 2019 May 2