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Peptide record

TPDB12516

Antibacterial Anticancer Cell-penetrating Peptides Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB12516
Antibacterial Anticancer Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia CPPsite3.0
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and CPPsite3.0, with an available 3D structural model.
Sequence
DILIIVGGKRRR
Physicochemical Analysis
C61H114N22O15
ANCEQHMFPSTWY
RI
1395.71
12.12
4
1
5
+3
3.25
-0.017
154.17
Mammalian: 1.1 hour Yeast: 3 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
3
R
0
N
1
D
0
C
0
E
0
Q
2
G
0
H
3
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
12
C61H114N22O15
1395.71
12.12
+3
3.25
-0.017
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µM

Target

Streptococcus agalactiae

Source & Reference

NA

Other

active against S. agalactiae (MIC 8 uM) demonstrated in vitro and in vivo.
Evidence 2 Activity

Activity

<1% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
<1% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Targeted and Intracellular Antibacterial Activity against S. agalactiae of the Chimeric Peptides Based on Pheromone and Cell-Penetrating Peptides. | ACS Appl Mater Interfaces | 2020
Evidence 3 Activity

Activity

0% Killing
Toxicity
64 µM
Cytotoxic
0% Killing | 64 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-1

Target

Intestinal Porcine Epithelial Cells IPEC-1

Source & Reference

NA
DBAASP
Targeted and Intracellular Antibacterial Activity against S. agalactiae of the Chimeric Peptides Based on Pheromone and Cell-Penetrating Peptides. | ACS Appl Mater Interfaces | 2020
Evidence 4 Activity

Activity

0% Killing
Toxicity
64 µM
Cytotoxic
0% Killing | 64 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Targeted and Intracellular Antibacterial Activity against S. agalactiae of the Chimeric Peptides Based on Pheromone and Cell-Penetrating Peptides. | ACS Appl Mater Interfaces | 2020