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Peptide record

TPDB12510

Antibacterial Anticancer Antifungal Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB12510
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
AWWRRTVAKVRK
Physicochemical Analysis
C72H117N25O14
NDCEQGHILMFPSY
R
1556.88
12.71
5
0
6
+5
0.65
-0.983
65.00
Mammalian: 4.4 hour Yeast: >20 hour E.coli: >10 hour
11000
706.54
1
Residue Composition
number
2
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
1
T
2
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 2
Chemical Descriptors
12
C72H117N25O14
1556.88
12.71
+5
0.65
-0.983
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.8 µM

Target

C. glutamicum ATCC 13032

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against C. glutamicum ATCC 13032 (MIC 0.8 uM), S.aureus ATCC 9144 (MIC 25 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µM

Target

S.aureus ATCC 9144

Source & Reference

dbAMP

Other

Active against C. glutamicum ATCC 13032 (MIC 0.8 uM), S.aureus ATCC 9144 (MIC 25 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal:
Evidence 3 Activity

Activity

MIC
Antibacterial
6.3 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP

Other

Active against C. glutamicum ATCC 13032 (MIC 0.8 uM), S.aureus ATCC 9144 (MIC 25 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal: C. albicans (MIC 25 uM), A. pullulans
Evidence 4 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP

Other

(MIC 0.8 uM), S.aureus ATCC 9144 (MIC 25 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal: C. albicans (MIC 25 uM), A. pullulans (MIC 50 uM), and Rhodotorula sp. (MIC
Evidence 5 Activity

Activity

MIC
Antibacterial
25 µM

Target

Candida albicans

Source & Reference

dbAMP

Other

P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal: C. albicans (MIC 25 uM), A. pullulans (MIC 50 uM), and Rhodotorula sp. (MIC 12.5 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
50 µM

Target

A. pullulans

Source & Reference

dbAMP

Other

(MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal: C. albicans (MIC 25 uM), A. pullulans (MIC 50 uM), and Rhodotorula sp. (MIC 12.5 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
0.8 µM

Target

C. glutamicum ATCC 13032

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against C. glutamicum ATCC 13032 (MIC 0.8 uM), S.aureus ATCC 9144 (MIC 25 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC
Evidence 8 Activity

Activity

MIC
Antifungal
25 µM

Target

S.aureus ATCC 9144

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against C. glutamicum ATCC 13032 (MIC 0.8 uM), S.aureus ATCC 9144 (MIC 25 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal:
Evidence 9 Activity

Activity

MIC
Antifungal
6.3 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against C. glutamicum ATCC 13032 (MIC 0.8 uM), S.aureus ATCC 9144 (MIC 25 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal: C. albicans (MIC 25 uM), A. pullulans
Evidence 10 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 0.8 uM), S.aureus ATCC 9144 (MIC 25 uM), P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal: C. albicans (MIC 25 uM), A. pullulans (MIC 50 uM), and Rhodotorula sp. (MIC
Evidence 11 Activity

Activity

MIC
Antifungal
25 µM

Target

Candida albicans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

P. aeruginosa ATCC 27853 (MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal: C. albicans (MIC 25 uM), A. pullulans (MIC 50 uM), and Rhodotorula sp. (MIC 12.5 uM).
Evidence 12 Activity

Activity

MIC
Antifungal
50 µM

Target

A. pullulans

Source & Reference

dbAMP CAFPdb Antifungipept

Other

(MIC 6.3 uM), and E. coli ATCC 25922 (MIC 12.5 uM). Antifungal: C. albicans (MIC 25 uM), A. pullulans (MIC 50 uM), and Rhodotorula sp. (MIC 12.5 uM).
Evidence 13 Activity

Activity

0% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
0% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity Relationship Studies of Shortened Analogues of the Antimicrobial Peptide EeCentrocin 1 From the Sea Urchin Echinus Esculentus. | J Pept Sci | 2019
Evidence 14 Activity

Activity

1.6% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
1.6% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-activity Relationship Studies of Shortened Analogues of the Antimicrobial Peptide EeCentrocin 1 From the Sea Urchin Echinus Esculentus. | J Pept Sci | 2019
Evidence 15 Activity

Activity

IC50
Toxicity
>100 µM
Cytotoxic
IC50 | >100 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Structure-activity Relationship Studies of Shortened Analogues of the Antimicrobial Peptide EeCentrocin 1 From the Sea Urchin Echinus Esculentus. | J Pept Sci | 2019
Evidence 16 Activity

Activity

IC50
Toxicity
100 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes:0% Hemolysis=25 µM 1.6% Hemolysis=200 µM | Cytotoxicity: MRC-5: IC50>100 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2020 Feb 26(2):e3233