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Peptide record

TPDB12509

Antibacterial Hemolysis Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB12509
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Hemolytic2 PD_Hemolysis
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RRLIWLILRLLR
Physicochemical Analysis
C77H137N25O13
ANDCEQGHKMFPSTYV
L
1621.09
12.88
4
0
8
+4
-2.03
0.758
227.50
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
339.28
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
5
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 5 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
12
C77H137N25O13
1621.09
12.88
+4
-2.03
0.758
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µM

Target

Escherichia coli BL21DE3

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against Gram- E. coli BL21DE3 (MIC 8 uM), P. aeruginosa ATCC27853 (MIC 8 uM), K. pneumoniae ATCC13883 (MIC 4 uM), S. enterica ATCC
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

Pseudomonas aeruginosa ATCC27853

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli BL21DE3 (MIC 8 uM), P. aeruginosa ATCC27853 (MIC 8 uM), K. pneumoniae ATCC13883 (MIC 4 uM), S. enterica ATCC14028 (MIC 8 uM), Gram+ B. subtilis
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

Klebsiella pneumoniae ATCC13883

Source & Reference

dbAMP DRAMP

Other

active against Gram- E. coli BL21DE3 (MIC 8 uM), P. aeruginosa ATCC27853 (MIC 8 uM), K. pneumoniae ATCC13883 (MIC 4 uM), S. enterica ATCC14028 (MIC 8 uM), Gram+ B. subtilis (MIC 10 uM), S. aureus ATCC25923 (MI
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

S. enterica ATCC14028

Source & Reference

dbAMP DRAMP

Other

21DE3 (MIC 8 uM), P. aeruginosa ATCC27853 (MIC 8 uM), K. pneumoniae ATCC13883 (MIC 4 uM), S. enterica ATCC14028 (MIC 8 uM), Gram+ B. subtilis (MIC 10 uM), S. aureus ATCC25923 (MIC 4 uM), S. pyogenes ATCC19615 (MI
Evidence 5 Activity

Activity

MIC
Antibacterial
10 µM

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

3 (MIC 8 uM), K. pneumoniae ATCC13883 (MIC 4 uM), S. enterica ATCC14028 (MIC 8 uM), Gram+ B. subtilis (MIC 10 uM), S. aureus ATCC25923 (MIC 4 uM), S. pyogenes ATCC19615 (MIC 4 uM), E. feacalis ATCC29212
Evidence 6 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus ATCC25923

Source & Reference

dbAMP DRAMP

Other

ae ATCC13883 (MIC 4 uM), S. enterica ATCC14028 (MIC 8 uM), Gram+ B. subtilis (MIC 10 uM), S. aureus ATCC25923 (MIC 4 uM), S. pyogenes ATCC19615 (MIC 4 uM), E. feacalis ATCC29212 (MIC 4 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
4 µM

Target

Streptococcus pyogenes ATCC19615

Source & Reference

dbAMP DRAMP

Other

rica ATCC14028 (MIC 8 uM), Gram+ B. subtilis (MIC 10 uM), S. aureus ATCC25923 (MIC 4 uM), S. pyogenes ATCC19615 (MIC 4 uM), E. feacalis ATCC29212 (MIC 4 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
4 µM

Target

E. feacalis ATCC29212

Source & Reference

dbAMP DRAMP

Other

. subtilis (MIC 10 uM), S. aureus ATCC25923 (MIC 4 uM), S. pyogenes ATCC19615 (MIC 4 uM), E. feacalis ATCC29212 (MIC 4 uM).
Evidence 9 Activity

Activity

<5% Hemolysis
Toxicity
5 µM
Hemolytic Cytotoxic
<5% Hemolysis | 5 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Salt-resistant short antimicrobial peptides. | Biopolymers | 2016
Evidence 10 Activity

Activity

12% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
12% Hemolysis | 10 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Salt-resistant short antimicrobial peptides. | Biopolymers | 2016
Evidence 11 Activity

Activity

35% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
35% Hemolysis | 25 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Salt-resistant short antimicrobial peptides. | Biopolymers | 2016
Evidence 12 Activity

Activity

58% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
58% Hemolysis | 50 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Salt-resistant short antimicrobial peptides. | Biopolymers | 2016
Evidence 13 Activity

Activity

78% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
78% Hemolysis | 100 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Salt-resistant short antimicrobial peptides. | Biopolymers | 2016
Evidence 14 Activity

Activity

% Hemolysis
Toxicity
5 %
Hemolytic
Hemolytic_activity: [Ref.26795535] 5% hemolysis at 5 µM, 12% hemolysis at 10 µM, 32% hemolysis at 25 µM, 60% hemolysis at 50 µM, 78% hemolysis at 100 µM against mice red cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biopolymers. 2016 May 106(3):345-56.
Evidence 15 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis